2,3-二甲基-4-硝基吡啶-N-氧化物合成路线 （共 41 条）
反应条件
1: trichlorophosphate / |Reflux 2: sodium hydroxide View Scheme
参考文献
Sharada; Satyanarayana Reddy; Sammaiah; Sumalatha
Asian Journal of Chemistry, 2013 , vol. 25, # 14 p. 7959 - 7966
反应条件
1: 94 percent / tert-BuOK / 42 h / 50 - 60 °C 2: 1) Ac2O, conc. H2SO4, 2) aq. NaOH / 1) 100-120 deg C, 5 h, 2) MeOH, rt, 3 h 3: 1) SOCl2, 2) MeONa / 1) CHCl3, reflux, 20 min, 2) MeOH, reflux, 1 h 4: 45 percent / m-chloroperbenzoic acid / CHCl3 / ice-cooling View Scheme
参考文献
Kubo; Oda; Kaneko; Satoh; Nohara
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 10 p. 2853 - 2858
反应条件
1: 82 percent / K2CO3 / 20 h / Heating 2: 110 °C 3: 10percent aq. HCl / 1.5 h / 90 °C 4: SOCl2 / CH2Cl2 / 0 °C View Scheme
参考文献
Kuehler, Thomas C.; Swanson, Marianne; Shcherbuchin, Vladimir; Larsson, Hakan; Mellgard, Bjoern; Sjoestroem, Jan-Eric
Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1777 - 1788
反应条件
1: trichlorophosphate / |Reflux 2: sodium hydroxide 3: acetic acid / methanol; toluene 4: sodium hydroxide / methanol View Scheme
参考文献
Sharada; Satyanarayana Reddy; Sammaiah; Sumalatha
Asian Journal of Chemistry, 2013 , vol. 25, # 14 p. 7959 - 7966
反应条件
1: 49 percent / 3 h / 100 °C 2: 70 percent / aq. sodium hydroxide / 1 h / 20 °C 3: 49 percent / thionyl chloride / CH2Cl2 / 1 h / 0 °C View Scheme
参考文献
Radl, Stanislav; Klecan, Ondrej; Havlicek, Jaroslav
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 6 p. 1447 - 1453
反应条件
hydrogen; acetic acid; palladium on activated charcoal T=60°C; P=2585.7 Torr; 12 h;
参考文献
Tanga; Bupp; Tochimoto
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 3 p. 717 - 727
反应条件
1: trichlorophosphate / |Reflux
2: sodium hydroxide
3: acetic acid / methanol; toluene
4: sodium hydroxide / methanol
View Scheme
参考文献
Sharada; Satyanarayana Reddy; Sammaiah; Sumalatha
Asian Journal of Chemistry, 2013 , vol. 25, # 14 p. 7959 - 7966
反应条件
1.1: 80 percent / POCl3 / CH2Cl2; dimethylformamide / 12 h / 25 °C
2.1: NaOH / dimethylsulfoxide / 1 h / 60 °C
2.2: 15 g / dimethylsulfoxide / 4 h / 60 °C
3.1: 5 h / 120 °C
4.1: NaOH / H2O / 1 h / 25 °C
5.1: 90 percent / SOCl2 / CH2Cl2 / 1 h / 25 °C
View Scheme
参考文献
Kohl; Sturm; Senn-Bilfinger; Simon; Kruger; Schaefer; Rainer; Figala; Klemm
Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1049 - 1057
反应条件
1: NaOMe / 16 h / 40 °C
2: 1.) Ac2O, 2.) 2 N aq. NaOH / 1.) 100 deg C, 3 h, 2.) 80 deg C, 3 h
3: SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C
4: aq. NaOH / ethanol / 4 h / 60 °C
5: 88 percent / 10percent aq. NaOCl, 6 N aq. NaOH / ethyl acetate / 0.5 h
View Scheme
参考文献
Kohl; Sturm; Senn-Bilfinger; Simon; Kruger; Schaefer; Rainer; Figala; Klemm
Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1049 - 1057
反应条件
1: 75 percent / phosphorus oxychloride / CH2Cl2 / 20 °C
2: 63 percent / 3 h / 100 °C
View Scheme
参考文献
Pingili, R. Reddy; Jambula, M. Reddy; Ganta, M. Reddy; Ghanta, M. Reddy; Sajja; Sundaram; Boluggdu, V. Bhaskar
Pharmazie, 2005 , vol. 60, # 11 p. 814 - 818
