1: mono-methyl malonate potassium salt With triethylamine; magnesium chloride in acetonitrile
T=0°C; 0.5 h;
2: 2-methyl-acryloyl chloride in acetonitrile
T=0°C; 0.5 h;
3: With hydrogenchloride in water
T=0°C; 0.75 h;
参考文献
Nawrat, Christopher C.; Palmer, Leoni I.; Blake, Alexander J.; Moody, Christopher J.
Journal of Organic Chemistry, 2013 , vol. 78, # 11 p. 5587 - 5603