丁氧羰基--环乙基-丙氨酸-羟基盐酸盐合成路线 （共 11 条）
反应条件
hydrogen; platinum(IV) oxide in ethanol
参考文献
Poss; Reid
Tetrahedron Letters, 1992 , vol. 33, # 11 p. 1411 - 1414
反应条件
triethylamine in 1,4-dioxane; water 4.5 h; Ambient temperature;
参考文献
Tsuda, Makoto; Muraoka, Yasuhiko; Nagai, Machiko; Aoyagi, Takaaki; Takeuchi, Tomio
Journal of Antibiotics, 1996 , vol. 49, # 9 p. 909 - 920
反应条件
hydrogen; rhodium in tetrahydrofuran
参考文献
G. D. Searle and Co.
Patent: US4495178 A1, 1985 ;
Title/Abstract Full Text Show Details
G. D. Searle and Co.
Patent: US4603121 A1, 1986 ;
反应条件
sodium hydroxide in 1,4-dioxane 1.) from 0deg C to RT, 3 h, 2.) RT, 17 h;
参考文献
Semple; Levy, Odile E.; Minami, Nathaniel K.; Owens, Timothy D.; Siev, Daniel V.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 20 p. 2305 - 2309
反应条件
1: 98 percent / H2, acetic acid / PtO2 / H2O / 18 h / 50 °C / 2327.2 Torr 2: 100 percent / 0.5 N aq. NaOH / dioxane / 1.) from 0deg C to RT, 3 h, 2.) RT, 17 h View Scheme
参考文献
Hoekstra, William J.; Sunder, Shyam S.; Cregge, Robert J.; Ashton, Louis A.; Stewart, Kenneth T.; King, Chi-Hsin R.
Tetrahedron, 1992 , vol. 48, # 2 p. 307 - 318
反应条件
1: 98.1 percent / H2 / 5percent Rh-Al2O3 / methanol / 56 h / Ambient temperature 2: 96.6 percent / 7 N HCl / 4 h / Heating 3: 100 percent / Et3N / H2O; dioxane / 4.5 h / Ambient temperature View Scheme
参考文献
Tsuda, Makoto; Muraoka, Yasuhiko; Nagai, Machiko; Aoyagi, Takaaki; Takeuchi, Tomio
Journal of Antibiotics, 1996 , vol. 49, # 9 p. 909 - 920
反应条件
1: 96.6 percent / 7 N HCl / 4 h / Heating 2: 100 percent / Et3N / H2O; dioxane / 4.5 h / Ambient temperature View Scheme
参考文献
Tsuda, Makoto; Muraoka, Yasuhiko; Nagai, Machiko; Aoyagi, Takaaki; Takeuchi, Tomio
Journal of Antibiotics, 1996 , vol. 49, # 9 p. 909 - 920
反应条件
1: 4-methylmorpholine / tetrahydrofuran / 0.33 h / -25 - -20 °C 2: diethyl ether / a) 0 deg C, 2 h, b) RT, overnight 3: HCl / dioxane; diethyl ether / 1 h / 0 °C 4: NaBH4 / tetrahydrofuran; H2O / 0.75 h / 0 °C 5: KOH / ethanol / 1.5 h / Ambient temperature View Scheme
参考文献
Barrish, Joel C.; Gordon, Eric; Alam, Masud; Lin, Pin-Fang; Bisacchi, Gregory S.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 12 p. 1758 - 1768
反应条件
borane in tetrahydrofuran
参考文献
Catalano, John G; Deaton, David N; Furfine, Eric S; Hassell, Annie M; McFadyen, Robert B; Miller, Aaron B; Miller, Larry R; Shewchuk, Lisa M; Willard Jr., Derril H; Wright, Lois L
Bioorganic and medicinal chemistry letters, 2004 , vol. 14, # 1 p. 275 - 278
反应条件
sodium hydrogencarbonate; acetic acid; citric acid in tetrahydrofuran; methanol; diethyl ether
参考文献
Japan Tobacco Inc.; YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD.
Patent: EP396065 A1, 1990 ;
EP 0396065 A1
