2,2,6,6-四氯环己酮合成路线 （共 21 条）
反应条件
1: 62 percent / TiCl4 / toluene / 48 h / 20 °C 2: (CH3CH2)3N / dimethylformamide / 6 h / 110 °C View Scheme
参考文献
Graevskaya; Azimov; Ryabova; Alekseeva; Anisimova; Syubaev; Granik
Pharmaceutical Chemistry Journal, 1998 , vol. 32, # 1 p. 41 - 44
反应条件
triethylamine in N,N-dimethyl-formamide T=100°C; Dehydrochlorination; 4 h;
参考文献
Ryabova; Bokanov; Isakovich; Kuzovkin; Grigor'ev; Levina; Shvedov; Granik
Pharmaceutical Chemistry Journal, 1996 , vol. 30, # 1 p. 38 - 40
参考文献
Rhone-Poulenc Industries
Patent: US4351969 A1, 1982 ;
参考文献
Fisons Limited
Patent: US4219505 A1, 1980 ;
Title/Abstract Full Text Show Details
Fisons Limited
Patent: US4268694 A1, 1981 ;
反应条件
1: 5.74 g / NH3; TiCl4 / toluene / 2 h / -1 - 10 °C 2: 2.32 g / (CH3CH2)3N / dimethylformamide / 5 h / 100 °C View Scheme
参考文献
Graevskaya; Azimov; Ryabova; Alekseeva; Anisimova; Syubaev; Granik
Pharmaceutical Chemistry Journal, 1998 , vol. 32, # 1 p. 41 - 44
反应条件
1: 99 percent / TiCl4 / toluene / 2 h / 20 °C 2: Et3N / dimethylformamide / 5 h / 95 - 100 °C 3: 86 percent / 2 h / 106 - 110 °C View Scheme
参考文献
Ryabova; Bokanov; Isakovich; Kuzovkin; Grigor'ev; Levina; Shvedov; Granik
Pharmaceutical Chemistry Journal, 1996 , vol. 30, # 1 p. 38 - 40
反应条件
1: 99 percent / TiCl4 / toluene / 2 h / 20 °C 2: Et3N / dimethylformamide / 5 h / 95 - 100 °C View Scheme
参考文献
Ryabova; Bokanov; Isakovich; Kuzovkin; Grigor'ev; Levina; Shvedov; Granik
Pharmaceutical Chemistry Journal, 1996 , vol. 30, # 1 p. 38 - 40
反应条件
aniline; titanium tetrachloride in water; toluene
参考文献
Osaka Yuki Kagaku Kogyo Kabushiki Kaisha
Patent: US4908479 A1, 1990 ;
反应条件
titanium tetrachloride in toluene T=20°C; Condensation; 2 h;
参考文献
Ryabova; Bokanov; Isakovich; Kuzovkin; Grigor'ev; Levina; Shvedov; Granik
Pharmaceutical Chemistry Journal, 1996 , vol. 30, # 1 p. 38 - 40
反应条件
1: 100 percent / NaBH4 / diethyl ether; methanol / 1 h / Ambient temperature
2: 92 percent / NaOH / H2O / 1.25 h / Ambient temperature
View Scheme
参考文献
Duhamel, Pierre; Leblond, Bertrand; Bidois-Sery, Laure; Poirier, Jean-Marie
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 16 p. 2265 - 2272
