3-苯基-1,2,4-噁二唑-5-甲酸乙酯合成路线 （共 10 条）
反应条件
1: benzonitrile With hydroxylamine hydrochloride; potassium carbonate 5 h; Heating / reflux; 2: oxalic acid monoethyl ester chloride in pyridine T=0 - 40°C; 2 h;
参考文献
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; CHEMON INC.
Patent: WO2008/153325 A1, 2008 ;
Location in patent: Page/Page column 79-80 ;
参考文献
Huhtiniemi, Tero; Suuronen, Tiina; Rinne, Valtteri M.; Wittekindt, Carsten; Lahtela-Kakkonen, Maija; Jarho, Elina; Wallen, Erik A. A.; Salminen, Antero; Poso, Antti; Leppaenen, Jukka
Journal of Medicinal Chemistry, 2008 , vol. 51, # 15 p. 4377 - 4380
反应条件
1: benzene; acetonitrile 2: aq. EtOH View Scheme
参考文献
Franz,J.E. et al.
Journal of Organic Chemistry, 1976 , vol. 41, p. 620 - 626
反应条件
in diethyl ether T=25°C; Condensation; Substitution; 2 h;
参考文献
Tyrkov; Ladyzhnikova; Solov'ev; Altukhov
Russian Journal of Organic Chemistry, 1999 , vol. 35, # 10 p. 1552 - 1552
反应条件
1: hydroxylamine hydrochloride; sodium carbonate / methanol; water / 12 h / Reflux 2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2.5 h / Reflux View Scheme
参考文献
Huguet, Florian; Melet, Armelle; Alves de Sousa, Rodolphe; Lieutaud, Aurelie; Chevalier, Jacqueline; Maigre, Laure; Deschamps, Patrick; Tomas, Alain; Leulliot, Nicolas; Pages, Jean-Marie; Artaud, Isabelle
ChemMedChem, 2012 , vol. 7, # 6 p. 1020 - 1030
参考文献
Franz,J.E. et al.
Journal of Organic Chemistry, 1976 , vol. 41, p. 620 - 626
反应条件
1: concentrated chloroform 2: 118 °C View Scheme
参考文献
Wurm
Chemische Berichte, 1889 , vol. 22, p. 3130,3132
参考文献
Bast,K. et al.
Chemische Berichte, 1972 , vol. 105, p. 2825 - 2840
反应条件
(i) Et3N, Et2O, (ii) /BRN= 635955/; Multistep reaction;
参考文献
Franz,J.E. et al.
Journal of Organic Chemistry, 1976 , vol. 41, p. 620 - 626
反应条件
1: N2H4*H2O / methanol / 0 °C
2: NaNO2, aq. HCl / acetic acid / 5 °C
3: toluene / 80 °C
View Scheme
参考文献
Palazzo,G.; Strani,G.
Gazzetta Chimica Italiana, 1960 , vol. 90, p. 1290 - 1298
