3-醛基-5-溴苯甲酸甲酯合成路线 （共 4 条）
反应条件
manganese(IV) dioxide in toluene
T=105°C; 7 h;
参考文献
TEIJIN LIMITED
Patent: EP1460059 A1, 2004 ;
Location in patent: Page 9-10 ;
反应条件
4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in acetonitrile
T=-10 - 20°C; 20 h;
参考文献
AiCuris GmbH and Co. KG
Patent: US2007/99885 A1, 2007 ;
Location in patent: Page/Page column 21 ;
反应条件
N-bromosuccinmide; sulfuric acid
T=0 - 20°C; 48 h;
参考文献
CHIESI FARMACEUTICI S.P.A.; AMARI, Gabriele; ARMANI, Elisabetta; RICCABONI, Mauro; RIZZI, Andrea; BAKER-GLENN, Charles; BLACKABY, Wesley; VAN DE PÖEL, Hervé; WHITTAKER, Ben
Patent: WO2014/86852 A1, 2014 ;
Location in patent: Page/Page column 67 ;
反应条件
1: 87 percent / dicyclohexylcarbodiimide; N,N'-dimethylaminopyridine / CH2Cl2 / 24 h / 20 °C
2: 57 percent / NBS; H2SO4 / 24 h / 20 °C
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参考文献
Nishinaga, Tohru; Tanatani, Aya; Oh, Keunchan; Moore, Jeffrey S.
Journal of the American Chemical Society, 2002 , vol. 124, # 21 p. 5934 - 5935
