1: PdCl2(CH3CN)2; p-benzoquinone / tetrahydrofuran / 24 h / Heating 2: K2CO3 / methanol / 1 h / 20 °C 3: diethyl azadicarboxylate (DEAD); PPh3 / tetrahydrofuran / 16 h / 20 °C 4: NH3 / methanol / 10 h / 80 °C 5: aq. CF3CO2H / 3 h / 50 °C View Scheme

1: PdCl2(CH3CN)2; p-benzoquinone / tetrahydrofuran / 24 h / Heating 2: diethyl azadicarboxylate (DEAD); PPh3 / tetrahydrofuran / 16 h / 20 °C 3: NH3 / methanol / 4 h / 20 °C 4: 4-dimethylaminopyridine; Et3N / acetonitrile / 24 h / 20 °C 5: aq. 30percent NH3 / acetonitrile / 5 h / 20 °C 6: aq. CF3CO2H / 3 h / 50 °C View Scheme