(S)-2-苯基-1-丙醇合成路线 （共 88 条）
反应条件
1: 94 percent / TiCl4 / CH2Cl2 / 0.75 h / -85 °C 2: Et3N / CH2Cl2 / 0.5 h / 0 °C 3: NaH / tetrahydrofuran / 15 h / Ambient temperature 4: 93 percent / 7.5N aq. KOH / tetrahydrofuran; methanol / 24 h / 55 °C 5: 1) lithium, 1-dimethylaminonaphthalene / 1) THF, -85 to -35 deg C, 2) THF, -20 deg C, 1 h View Scheme
参考文献
Harada, Toshiro; Hayashiya, Toshio; Wada, Isao; Iwa-ake, Naoko; Oku, Akira
Journal of the American Chemical Society, 1987 , vol. 109, # 2 p. 527 - 532
反应条件
1: NaH / tetrahydrofuran / 15 h / Ambient temperature 2: 93 percent / 7.5N aq. KOH / tetrahydrofuran; methanol / 24 h / 55 °C 3: 1) lithium, 1-dimethylaminonaphthalene / 1) THF, -85 to -35 deg C, 2) THF, -20 deg C, 1 h View Scheme
参考文献
Harada, Toshiro; Hayashiya, Toshio; Wada, Isao; Iwa-ake, Naoko; Oku, Akira
Journal of the American Chemical Society, 1987 , vol. 109, # 2 p. 527 - 532
反应条件
1: Et3N / CH2Cl2 / 0.5 h / 0 °C 2: NaH / tetrahydrofuran / 15 h / Ambient temperature 3: 93 percent / 7.5N aq. KOH / tetrahydrofuran; methanol / 24 h / 55 °C 4: 1) lithium, 1-dimethylaminonaphthalene / 1) THF, -85 to -35 deg C, 2) THF, -20 deg C, 1 h View Scheme
参考文献
Harada, Toshiro; Hayashiya, Toshio; Wada, Isao; Iwa-ake, Naoko; Oku, Akira
Journal of the American Chemical Society, 1987 , vol. 109, # 2 p. 527 - 532
反应条件
1: 93 percent / 7.5N aq. KOH / tetrahydrofuran; methanol / 24 h / 55 °C 2: 1) lithium, 1-dimethylaminonaphthalene / 1) THF, -85 to -35 deg C, 2) THF, -20 deg C, 1 h View Scheme
参考文献
Harada, Toshiro; Hayashiya, Toshio; Wada, Isao; Iwa-ake, Naoko; Oku, Akira
Journal of the American Chemical Society, 1987 , vol. 109, # 2 p. 527 - 532
反应条件
1: With ozone in methanol T=-78°C; 0.116667 h; 2: With sodium tetrahydroborate in methanol T=25°C; 10 h; Further stages.;
参考文献
Demel, Peter; Keller, Manfred; Breit, Bernhard
Chemistry - A European Journal, 2006 , vol. 12, # 25 p. 6669 - 6683
反应条件
lithium aluminium tetrahydride in diethyl ether
参考文献
Coulbeck, Elliot; Eames, Jason
Synlett, 2008 , # 3 p. 333 - 338
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 5 h; Ambient temperature;
参考文献
Chen, Ming-Yi; Fang, Jim-Min; Tsai, Yeun-Min; Yeh, Ru-Long
Journal of the Chemical Society, Chemical Communications, 1991 , # 22 p. 1603 - 1604
反应条件
boron trifluoride diethyl etherate in tetrahydrofuran 0.25 h;
参考文献
Botuha, Candice; Haddad, Mansour; Larcheveque, Marc
Tetrahedron Asymmetry, 1998 , vol. 9, # 11 p. 1929 - 1931
反应条件
lipase from Pseudomonas Cepacia in cyclohexane T=30°C;
参考文献
Kawasaki, Masashi; Goto, Michimasa; Kawabata, Shigeki; Kometani, Tadashi
Tetrahedron Asymmetry, 2001 , vol. 12, # 4 p. 585 - 596
反应条件
1: phenyl-magnesium bromide With copper(I) bromide dimethylsulfide complex in tetrahydrofuran Cooling with ice; 2: (Z)-1-phenylhex-4-en-3-yl pyridine-2-carboxylate in tetrahydrofuran T=-60 - -40°C; optical yield given as percent eeFurther stages;
参考文献
Kiyotsuka, Yohei; Acharya, Hukum P.; Katayama, Yuji; Hyodo, Tomonori; Kobayashi, Yuichi
Organic Letters, 2008 , vol. 10, # 9 p. 1719 - 1722
