(S)-2-苯基-1-丙醇合成路线 （共 88 条）
反应条件
in toluene T=0°C; 1 h; Yield given. Yields of byproduct given;
参考文献
Yoshida, Hifumi; Takada, Akinori; Mitsunobu, Oyo
Tetrahedron Letters, 1998 , vol. 39, # 19 p. 3007 - 3010
反应条件
2: NaH 4: Bu3SnH, azobisisobutyronitrile (AIBN) / benzene / 0.5 h / 80 °C 5: 76 percent / LiAlH4 / tetrahydrofuran / 5 h / Ambient temperature View Scheme
参考文献
Chen, Ming-Yi; Fang, Jim-Min; Tsai, Yeun-Min; Yeh, Ru-Long
Journal of the Chemical Society, Chemical Communications, 1991 , # 22 p. 1603 - 1604
反应条件
1: NaH 3: Bu3SnH, azobisisobutyronitrile (AIBN) / benzene / 0.5 h / 80 °C 4: 76 percent / LiAlH4 / tetrahydrofuran / 5 h / Ambient temperature View Scheme
参考文献
Chen, Ming-Yi; Fang, Jim-Min; Tsai, Yeun-Min; Yeh, Ru-Long
Journal of the Chemical Society, Chemical Communications, 1991 , # 22 p. 1603 - 1604
反应条件
1: NaH 3: nBu3SnH, azobisisobutyronitrile (AIBN) / benzene / 80 °C / other xanthates; other reductant; var. temp. and solvents.; also with irradiation 4: 76 percent / LiAlH4 / tetrahydrofuran / 5 h / Ambient temperature View Scheme
参考文献
Chen, Ming-Yi; Fang, Jim-Min; Tsai, Yeun-Min; Yeh, Ru-Long
Journal of the Chemical Society, Chemical Communications, 1991 , # 22 p. 1603 - 1604
反应条件
1: nBu3SnH, azobisisobutyronitrile (AIBN) / benzene / 80 °C / other xanthates; other reductant; var. temp. and solvents.; also with irradiation 2: 76 percent / LiAlH4 / tetrahydrofuran / 5 h / Ambient temperature View Scheme
参考文献
Chen, Ming-Yi; Fang, Jim-Min; Tsai, Yeun-Min; Yeh, Ru-Long
Journal of the Chemical Society, Chemical Communications, 1991 , # 22 p. 1603 - 1604
反应条件
1: Bu3SnH, azobisisobutyronitrile (AIBN) / benzene / 0.5 h / 80 °C 2: 76 percent / LiAlH4 / tetrahydrofuran / 5 h / Ambient temperature View Scheme
参考文献
Chen, Ming-Yi; Fang, Jim-Min; Tsai, Yeun-Min; Yeh, Ru-Long
Journal of the Chemical Society, Chemical Communications, 1991 , # 22 p. 1603 - 1604
反应条件
1.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere 1.2: 1 h / 20 - 40 °C 1.3: 20 - 30 °C 2.1: Pseudomonas cepacia lipase / tert-butyl methyl ether / 20 °C / Enzymatic reaction 3.1: palladium 10 on activated carbon; hydrogen / methanol View Scheme
参考文献
Serra, Stefano
Tetrahedron Asymmetry, 2011 , vol. 22, # 6 p. 619 - 628
反应条件
1.1: diethyl ether / 3.5 h / 0 - 20 °C / Inert atmosphere 1.2: Cooling with ice 2.1: toluene-4-sulfonic acid; hydroquinone / benzene / Reflux; Azeotropic water removal 3.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere 3.2: 1 h / 20 - 40 °C 3.3: 20 - 30 °C 4.1: Pseudomonas cepacia lipase / tert-butyl methyl ether / 20 °C / Enzymatic reaction 5.1: palladium 10 on activated carbon; hydrogen / methanol View Scheme
参考文献
Serra, Stefano
Tetrahedron Asymmetry, 2011 , vol. 22, # 6 p. 619 - 628
反应条件
1: Pseudomonas cepacia lipase / tert-butyl methyl ether / 20 °C / Enzymatic reaction 2: palladium 10 on activated carbon; hydrogen / methanol View Scheme
参考文献
Serra, Stefano
Tetrahedron Asymmetry, 2011 , vol. 22, # 6 p. 619 - 628
反应条件
1.1: toluene-4-sulfonic acid; hydroquinone / benzene / Reflux; Azeotropic water removal 2.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere 2.2: 1 h / 20 - 40 °C 2.3: 20 - 30 °C 3.1: Pseudomonas cepacia lipase / tert-butyl methyl ether / 20 °C / Enzymatic reaction 4.1: palladium 10 on activated carbon; hydrogen / methanol View Scheme
参考文献
Serra, Stefano
Tetrahedron Asymmetry, 2011 , vol. 22, # 6 p. 619 - 628
