1: N-Boc-pyrrolidine With sec.-butyllithium; (-)-sparteine in diethyl ether T=-78 - -70°C; Inert atmosphere; 2: carbon dioxide in diethyl ether T=-78 - 20°C; 3: With hydrogenchloride in diethyl ether; water pH=2; enantioselective reaction;
参考文献
Fournier, Anne M.; Brown, Robert A.; Farnaby, William; Miyatake-Ondozabal, Hideki; Clayden, Jonathan
Organic Letters, 2010 , vol. 12, # 10 p. 2222 - 2225
sodium periodate; ReCl3 in tetrachloromethane; acetonitrile T=25°C;
参考文献
Dieter, R. Karl; Oba, Gabriel; Chandupatla, Kishan R.; Topping, Chris M.; Lu, Kai; Watson, Rhett T.
Journal of Organic Chemistry, 2004 , vol. 69, # 9 p. 3076 - 3086
1.1: sec-butyllithium; (-)-sparteine / diethyl ether / 1 h / -78 °C 1.2: CuCN; LiCl / diethyl ether; tetrahydrofuran / 1 h / -78 - -60 °C 1.3: diethyl ether; tetrahydrofuran / 12 h / -60 - 25 °C 2.1: NaIO4; ReCl3*H2O / CCl4; acetonitrile / 25 °C View Scheme
参考文献
Dieter, R. Karl; Oba, Gabriel; Chandupatla, Kishan R.; Topping, Chris M.; Lu, Kai; Watson, Rhett T.
Journal of Organic Chemistry, 2004 , vol. 69, # 9 p. 3076 - 3086
