Boc-D-脯氨酸合成路线

参考文献

ZALICUS PHARMACEUTICALS LTD.; PAJOUHESH, Hassan, A.; HOLLAND, Richard; ZHANG, Lingyun; PAJOUHESH, Hossein, O.; LAMONTAGNE, Jason; WHELAN, Brendan; SHORT, Glenn, F., III.; ROMERO, Donna, L.
Patent: WO2013/131018 A1, 2013 ;
Location in patent: Page/Page column 38 ;

37784-17-1Boc-D-脯氨酸+

77-78-1硫酸二甲酯

73323-65-6Boc-D-脯氨酸甲酯

参考文献

Chakraborti, Asit K.; Basak, Anindita; Grover, Vikas
Journal of Organic Chemistry, 1999 , vol. 64, # 21 p. 8014 - 8017

186581-53-3重氮甲烷+

37784-17-1Boc-D-脯氨酸

73323-65-6Boc-D-脯氨酸甲酯

参考文献

Becker, Y.; Eisenstadt, A.; Stille, J. K.
Journal of Organic Chemistry, 1980 , vol. 45, # 11 p. 2145 - 2151

37784-17-1Boc-D-脯氨酸

70138-72-6(2R)-2-氨甲酰基吡咯烷-1-甲酸叔丁酯

参考文献

AstraZeneca AB; NPS PHARMACEUTICALS, INC.
Patent: US2007/259926 A1, 2007 ;
Location in patent: Page/Page column 9 ;
US 20070259926 A1

37784-17-1Boc-D-脯氨酸

128510-88-3(R)-2-(甲苯磺酰氧基甲基)吡咯烷-1-甲酸叔丁酯

参考文献

Cardillo, Giuliana; Gentilucci, Luca; Qasem, Ahmed R.; Sgarzi, Fabio; Spampinato, Santi
Journal of Medicinal Chemistry, 2002 , vol. 45, # 12 p. 2571 - 2578

37784-17-1Boc-D-脯氨酸

132482-06-5(R)-叔丁基 2-(2-羟基乙基)吡咯烷-1-羧酸

参考文献

Schjoth-Eskesen, Christina; Jensen, Henrik Helligso
Synthetic Communications, 2009 , vol. 39, # 18 p. 3243 - 3253

37784-17-1Boc-D-脯氨酸

137496-71-0(S)-1-叔丁氧羰基-2-甲基吡咯烷

参考文献

Donner
Tetrahedron Letters, 1995 , vol. 36, # 8 p. 1223 - 1226

37784-17-1Boc-D-脯氨酸

138108-72-2(R)-1-Boc-3-羟甲基吡咯烷

参考文献

US2013/184313 A1, ;

Paragraph 1653; 1654 ;

6066-82-6N-羟基丁二酰亚胺+

37784-17-1Boc-D-脯氨酸

102185-34-2

参考文献

Gauchot, Vincent; Schmitzer, Andreea R.
Journal of Organic Chemistry, 2014 , vol. 79, # 6 p. 2694 - 2701

37784-17-1Boc-D-脯氨酸

101555-60-6

参考文献

Abele, Stefan; Voegtli, Kurt; Seebach, Dieter
Helvetica Chimica Acta, 1999 , vol. 82, # 10 p. 1539 - 1558