2-(3,4,5-三甲氧基苯基)乙醇合成路线 （共 20 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 5°C; 3 h;
参考文献
Labruere, Raphael; Gautier, Benoit; Testud, Marlene; Seguin, Johanne; Lenoir, Christine; Desbene-Finck, Stephanie; Helissey, Philippe; Garbay, Christiane; Chabot, Guy G.; Vidal, Michel; Giorgi-Renault, Sylviane
ChemMedChem, 2010 , vol. 5, # 12 p. 2016 - 2025
反应条件
diisobutylaluminium hydride in tetrahydrofuran; methanol; hexane; ethyl acetate
参考文献
SUMITOMO PHARMACEUTICALS COMPANY, LIMITED
Patent: EP801071 A1, 1997 ;
反应条件
1: With benzo[1,3,2]dioxaborole; (S)-QUINAPRh(+)OTf(-) in tetrahydrofuran T=20°C; 32 h; 2: With sodium hydroxide; dihydrogen peroxide in tetrahydrofuran; ethanol T=20°C; Title compound not separated from byproducts;
参考文献
Black, Antonia; Brown, John M.; Pichont, Christophe
Chemical Communications, 2005 , # 42 p. 5284 - 5286
反应条件
lithium aluminium tetrahydride
参考文献
Majchrzak; Kotelko; Guryn; Lambert; Szadowska; Kowalczyk
Journal of Pharmaceutical Sciences, 1983 , vol. 72, # 3 p. 304 - 306
反应条件
1.1: toluene-4-sulfonic acid / benzene / |Inert atmosphere; |Reflux; |Dean-Stark 2.1: 9-bora-bicyclo[3.3.1]nonane / toluene / 18 h / |Inert atmosphere; |Reflux 2.2: 2 h / 20 °C / |Inert atmosphere; |Reflux View Scheme
参考文献
Soderquist, John A.; Kock, Iveliz; Estrella, Maria E.
Organic Process Research and Development, 2006 , vol. 10, # 5 p. 1076 - 1079
反应条件
sulfuric acid; sodium nitrite T=50°C;
参考文献
Slotta; Mueller
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1936 , vol. 238, p. 14,22
反应条件
lithium aluminium tetrahydride in diethyl ether
参考文献
Major,R.T.; Ohly,K.W.
Journal of Medicinal and Pharmaceutical Chemistry, 1961 , vol. 4, p. 51 - 65
反应条件
sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; dihydrogen peroxide 1.) THF, 2 h, 2.) THF, RT, 1 h; Yield given. Multistep reaction;
参考文献
Rosowsky, Andre; Papoulis, Andrew T.; Queener, Sherry F.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 6 p. 913 - 918
反应条件
1: 1.) n-BuLi / 1.) hexane, THF, 1 h, 2.) hexane, THF, 0.5 h 2: 1.) 9-BBN, 2.) aq. NaOH, H2O2 / 1.) THF, 2 h, 2.) THF, RT, 1 h View Scheme
参考文献
Rosowsky, Andre; Papoulis, Andrew T.; Queener, Sherry F.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 6 p. 913 - 918
反应条件
1: thionyl chloride / dichloromethane 2: dimethyl sulfoxide 3: potassium hydroxide; water / ethanol / 15 h / |Reflux 4: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 20 °C / |Reflux View Scheme
参考文献
Zheng, Cheng; Guo, Yibing; Meng, Ying; Dou, Sufeng; Shao, Jian; Yang, Yumin
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2013 , vol. 52, # 5 p. 654 - 664
