2,2-二甲基-苯并二氢吡喃-4-酮合成路线 （共 66 条）
反应条件
1: H2, NaOH / Raney-Ni / ethanol / 1 h / 3800 Torr / Ambient temperature
2: 98 percent / 1,4-diazabicyclo<2.2.2>octane / dimethylformamide / 2 h / Ambient temperature
3: 94 percent / N,N-dimethylaniline / 1 h / 200 °C
4: 94 percent / KOH / methanol / 1 h / Heating
5: Raney-Ni / ethanol / Ambient temperature
View Scheme
参考文献
Sebok; Timar; Eszenyi; Patonay
Journal of Organic Chemistry, 1994 , vol. 59, # 21 p. 6318 - 6321
反应条件
1: 98 percent / Et3N / diethyl ether / 0.25 h / -5 °C
2: 97 percent / diethyl ether / 0.25 h / -5 °C
3: 86 percent / H2 / 10percent Pd/C / ethanol / 3800 Torr / Ambient temperature
View Scheme
参考文献
Sebok; Timar; Eszenyi; Patonay
Journal of Organic Chemistry, 1994 , vol. 59, # 21 p. 6318 - 6321
反应条件
nickel in ethanol
1 h; Ambient temperature;
参考文献
Sebok; Timar; Eszenyi; Patonay
Journal of Organic Chemistry, 1994 , vol. 59, # 21 p. 6318 - 6321
反应条件
water; sodium chloride in dimethyl sulfoxide
T=155 - 165°C;
参考文献
Saengchantara, Suthiweth T.; Wallace, Timothy W.
Tetrahedron, 1990 , vol. 46, # 8 p. 3029 - 3036
反应条件
hydrogenchloride in tetrahydrofuran; water
1.5 h; Heating;
参考文献
Gabbutt, Christopher D.; Hepworth, John D.; Heron, B. Mark; Kanjia, Magan
Tetrahedron, 1994 , vol. 50, # 3 p. 827 - 834
反应条件
1: 100 percent / diethyl ether / 0.25 h / -5 °C
2: 87 percent / H2 / 10percent Pd/C / ethanol / 3800 Torr / Ambient temperature
View Scheme
参考文献
Sebok; Timar; Eszenyi; Patonay
Journal of Organic Chemistry, 1994 , vol. 59, # 21 p. 6318 - 6321
反应条件
1: 97 percent / diethyl ether / 0.25 h / -5 °C
2: 86 percent / H2 / 10percent Pd/C / ethanol / 3800 Torr / Ambient temperature
View Scheme
参考文献
Sebok; Timar; Eszenyi; Patonay
Journal of Organic Chemistry, 1994 , vol. 59, # 21 p. 6318 - 6321
反应条件
triethylamine in cyclohexane
T=20°C; photo-Fries rearrangement; 1 h; Inert atmosphereIrradiation;
参考文献
Lopez, Cecilia Samaniego; Erra-Balsells, Rosa; Bonesi, Sergio M.
Tetrahedron Letters, 2010 , vol. 51, # 33 p. 4387 - 4390
反应条件
pyrrolidine in toluene
1) 24 h, 2) heating;
参考文献
Kabbe, Hans-Joachim; Widdig, Arno
Angewandte Chemie, 1982 , vol. 94, # 4 p. 254 - 262
反应条件
1.1: tBuOK; BuLi / tetrahydrofuran; hexane / 2 h / -95 °C
1.2: triisopropyl borate / tetrahydrofuran; hexane / -95 - 20 °C
1.3: 85 percent / toluene / 25 °C
2.1: 36 percent / K2CO3 / Pd(PPh3)4 / tetrahydrofuran / 80 °C
3.1: 75 percent / Amberlyst-15 (R) / CHCl3 / 2 h
View Scheme
参考文献
Deagostino, Annamaria; Farina, Vittorio; Prandi, Cristina; Zavattaro, Chiara; Venturello, Paolo
European Journal of Organic Chemistry, 2006 , # 15 p. 3451 - 3456
