6-溴-3-甲基-3H-咪唑并[4,5-b]吡啶合成路线 （共 4 条）
反应条件
bromine in water; acetic acid 5 h; Heating;
参考文献
Yutilov; Lopatinskaya; Smolyar; Gres'Ko
Russian Journal of Organic Chemistry, 2005 , vol. 41, # 3 p. 450 - 454
参考文献
MERZ PHARMA GMBH and CO. KGAA; HENRICH, Markus; WEIL, Tanja; HECHENBERGER, Mirko; MUeLLER, Sibylle; KAUSS, Valerjans; ZEMRIBO, Ronalds; ERDMANE, Elina; SMITS, Gints
Patent: WO2011/15343 A1, 2011 ;
Location in patent: Page/Page column 43 ;
WO 2011/015343 A1
反应条件
1: water; tetrahydrofuran / 12 h / 20 °C 2: SnCl2·2H2O / ethyl acetate / 3.5 h / Reflux 3: 3 h / Reflux View Scheme
参考文献
MERZ PHARMA GMBH and CO. KGAA; HENRICH, Markus; WEIL, Tanja; HECHENBERGER, Mirko; MUeLLER, Sibylle; KAUSS, Valerjans; ZEMRIBO, Ronalds; ERDMANE, Elina; SMITS, Gints
Patent: WO2011/15343 A1, 2011 ;
WO 2011/015343 A1
参考文献
Grivas; Lindstrom
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 2 p. 467 - 471
