乙基4-羟基-3-甲基-1-苯并呋喃-2-羧酸酯合成路线 （共 12 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 4 h;
参考文献
Masubuchi, Miyako; Ebiike, Hirosato; Kawasaki, Ken-Ichi; Sogabe, Satoshi; Morikami, Kenji; Shiratori, Yasuhiko; Tsujii, Shinji; Fujii, Toshihiko; Sakata, Kiyoaki; Hayase, Michiko; Shindoh, Hidetoshi; Aoki, Yuko; Ohtsuka, Tatsuo; Shimma, Nobuo
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 20 p. 4463 - 4478
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane; water
Heating;
参考文献
Shekarchi; Ellahiyan; Akbarzadeh; Shafiee
Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 3 p. 427 - 433
反应条件
1: K2CO3 / acetone / 15 h / 60 °C
2: NaOEt / ethanol / 20 h / 0 °C
View Scheme
参考文献
Masubuchi, Miyako; Kawasaki, Ken-ichi; Ebiike, Hirosato; Ikeda, Yoshihiko; Tsujii, Shinji; Sogabe, Satoshi; Fujii, Toshihiko; Sakata, Kiyoaki; Shiratori, Yasuhiko; Aoki, Yuko; Ohtsuka, Tatsuo; Shimma, Nobuo
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 14 p. 1833 - 1837
反应条件
1: 4 N aq. HCl / methanol; dioxane / 50 °C
2: K2CO3 / acetone / 15 h / 60 °C
3: NaOEt / ethanol / 20 h / 0 °C
View Scheme
参考文献
Masubuchi, Miyako; Kawasaki, Ken-ichi; Ebiike, Hirosato; Ikeda, Yoshihiko; Tsujii, Shinji; Sogabe, Satoshi; Fujii, Toshihiko; Sakata, Kiyoaki; Shiratori, Yasuhiko; Aoki, Yuko; Ohtsuka, Tatsuo; Shimma, Nobuo
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 14 p. 1833 - 1837
反应条件
1: n-BuLi / tetrahydrofuran / 1 h / -78 - 20 °C
2: 4 N aq. HCl / methanol; dioxane / 50 °C
3: K2CO3 / acetone / 15 h / 60 °C
4: NaOEt / ethanol / 20 h / 0 °C
View Scheme
参考文献
Masubuchi, Miyako; Kawasaki, Ken-ichi; Ebiike, Hirosato; Ikeda, Yoshihiko; Tsujii, Shinji; Sogabe, Satoshi; Fujii, Toshihiko; Sakata, Kiyoaki; Shiratori, Yasuhiko; Aoki, Yuko; Ohtsuka, Tatsuo; Shimma, Nobuo
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 14 p. 1833 - 1837
参考文献
Whalley
Journal of the Chemical Society, 1951 , p. 3235,3238
反应条件
1: diethyl ether; zinc chloride; hydrogen chloride / Erwaermen des Reaktionsprodukts mit Wasser
2: aq.-ethanolic KOH-solution
View Scheme
参考文献
Whalley
Journal of the Chemical Society, 1951 , p. 3235,3238
参考文献
Whalley
Journal of the Chemical Society, 1951 , p. 3235,3238
反应条件
1: 86 percent / Br2 / CHCl3 / 1 h / Ambient temperature
2: 63 percent / CrO3, CH3COOH / H2O / 1 h / Ambient temperature
3: 76 percent / NaHCO3 / CH2Cl2 / 24 h / Ambient temperature
4: KOH / ethanol / 1 h / Heating
5: Cu, quinoline / 0.75 h / 200 °C
View Scheme
参考文献
Cherkaoui, Omar; Nebois, Pascal; Fillion, Houda
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 3 p. 457 - 458
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C;
参考文献
Masubuchi, Miyako; Ebiike, Hirosato; Kawasaki, Ken-Ichi; Sogabe, Satoshi; Morikami, Kenji; Shiratori, Yasuhiko; Tsujii, Shinji; Fujii, Toshihiko; Sakata, Kiyoaki; Hayase, Michiko; Shindoh, Hidetoshi; Aoki, Yuko; Ohtsuka, Tatsuo; Shimma, Nobuo
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 20 p. 4463 - 4478
