4-(4-吗啉基甲基)苯腈合成路线 （共 6 条）
反应条件
potassium carbonate in acetonitrile 0.5 h; Inert atmosphere;
参考文献
LIVERPOOL SCHOOL OF TROPICAL MEDICINE; O'NEILL, Paul; BIAGINI, Giancarlo; WARD, Stephen A.; BERRY, Neil Graham; NIXON, Gemma; AMEWU, Richard K.; PIDATHALA, Chandrakala; HONG, Weiqian David; GIBBONS, Peter; LEUNG, Suet Ching; PACOREL, Benedicte; SHARMA, Raman; LAWRENSON, Alexandre S.; SHONE, Alison E.; SRIVASTAVA, Abhishek; WARMAN, Ashley J.
Patent: WO2012/69856 A1, 2012 ;
Location in patent: Page/Page column 67 ;
反应条件
NHC-Pd(II)-Im; sodium hydroxide in water T=50°C; 3 h; Inert atmosphereSchlenk technique;
参考文献
Chen, Wen-Xin; Zhang, Cai-Yun; Lu, Jian-Mei
Journal of Chemical Research, 2013 , vol. 37, # 10 p. 611 - 614
反应条件
sodium cyanoborohydride; acetic acid in 1,2-dichloro-ethane
参考文献
ELI LILLY AND COMPANY
Patent: WO2007/28083 A2, 2007 ;
Location in patent: Page/Page column 91 ;
WO 2007/028083 A2
参考文献
Grochowski,E.; Boleslawska,T.
Bulletin de l'Academie Polonaise des Sciences, Serie des Sciences Chimiques, 1972 , vol. 20, p. 405 - 409
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 2: With water in tetrahydrofuran T=0°C;
参考文献
ELI LILLY AND COMPANY
Patent: WO2007/28083 A2, 2007 ;
Location in patent: Page/Page column 91-92 ;
WO 2007/028083 A2
反应条件
1: With diisobutylaluminium hydride in tetrahydrofuran; methanol; hexane T=-78°C; 2 h; 2: With hydrogenchloride; methanol in tetrahydrofuran; hexane T=20°C;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1612204 A1, 2006 ;
Location in patent: Page/Page column 40 ;
