4,5-二甲基-1,3-二氧杂环戊烯-2-酮合成路线 （共 13 条）
反应条件
in dichloromethane; N,N-dimethyl-aniline; toluene
参考文献
E. R. Squibb and Sons, Inc.
Patent: US6117885 A1, 2000 ;
反应条件
1: With N,N-dimethyl-aniline in dichloromethane T=20°C; 2 h; 2: T=160°C; 4 h;
参考文献
Sahu, Devi Prasad
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2002 , vol. 41, # 8 p. 1722 - 1723
反应条件
selenium(IV) oxide in 1,4-dioxane
参考文献
Metabasis Therapeutics, Inc.
Patent: US6756360 B1, 2004 ;
Location in patent: Page column 162 ;
反应条件
N-chloro-succinimide in tetrachloromethane 80 h; Ambient temperatureIrradiation;
参考文献
Sakamoto; Ikeda; Tsukamoto
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 6 p. 2241 - 2248
反应条件
chlorine in dichloromethane T=43 - 45°C; further solvents; Product distribution;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 36, # 1 p. 394 - 397
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane T=77°C; 6 h;
参考文献
S.I.M.S. S.r.l. - SOCIETA ITALIANA MEDICINALI SCANDICCI
Patent: WO2008/12852 A1, 2008 ;
Location in patent: Page/Page column 23; 36 ;
反应条件
N-bromosuccinmide in tetrachloromethane
参考文献
Boykin, David W.; Rahmathullah, M. Syed; Tidwell, Richard R.; Hall, James E.
Patent: US2002/19437 A1, 2002 ;
反应条件
N-bromosuccinmide in tetrachloromethane
参考文献
University of Pittsburgh
Patent: US2002/193596 A1, 2002 ;
反应条件
2,2'-azo-bisisobutyronitrile in benzene T=20°C; 0.5 h; Heating / reflux;
参考文献
TOYAMA CHEMICAL CO., LTD.; Hirono, Shuichi; Shiozawa, Shunichi
Patent: EP1445249 A1, 2004 ;
Location in patent: Page 116 ;
反应条件
1: 80.8 percent / sodium bicarbonate, α,α'-azobisisobutyronitrile, Br2 / CCl4 / 1.08 h / 70 °C 2: 1.) potassium bicarbonate / 1.) DMF, 0 deg C, 3 h; 2.) 0 deg C, 3 h 3: 60 percent / 1N HCl / acetonitrile / 0.5 h / 0 - 5 °C / pH=2.0 View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 32, # 6 p. 2241 - 2248
