反应条件
1: N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium(0); copper(l) iodide / 8 h / 80 °C / |Inert atmosphere
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C / |Inert atmosphere
3: hydrogen; palladium / ethyl acetate / 0.67 h / 20 °C
4: ammonium chloride; acetic acid / water / 4 h / |Reflux
View Scheme
参考文献
Galli, Ubaldina; Mesenzani, Ornella; Coppo, Camilla; Sorba, Giovanni; Canonico, Pier Luigi; Tron, Gian Cesare; Genazzani, Armando A.
European Journal of Medicinal Chemistry, 2012 , vol. 55, p. 58 - 66,9
