乙基 2-氨基-2-氰基乙酸酯 4-甲基苯硫nate合成路线 （共 10 条）
反应条件
hydrogenchloride; sodium nitrite in methanol; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; acetic acid; ethyl acetate; toluene
参考文献
Lonza Ltd.
Patent: US5003099 A1, 1991 ;
反应条件
nickel monoaluminide
参考文献
Lonza, Ltd.
Patent: US4071550 A1, 1978 ;
参考文献
Lu, Xiaoyun; Liu, Xiaobo; Wan, Baojie; Franzblau, Scott G.; Chen, Lili; Zhou, Changlin; You, Qidong
European Journal of Medicinal Chemistry, 2012 , vol. 49, p. 164 - 171
参考文献
Lonza Ltd.
Patent: US5003099 A1, 1991 ;
反应条件
1: NaHCO3, Na2S2O4 / H2O / 20 - 35 °C 2: diethyl ether; ethanol / -20 °C / overnight View Scheme
参考文献
Meester, Johan W. G. De; Plas, Henk C. van der; Middelhoven, Wouter J.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 441 - 451
反应条件
in diethyl ether; ethanol T=-20°C; overnight; Yield given;
参考文献
Meester, Johan W. G. De; Plas, Henk C. van der; Middelhoven, Wouter J.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 441 - 451
反应条件
1.1: phosphoric acid; sodium nitrite / water / 1 h / 10 - 40 °C 1.2: 45 °C 2.1: sodium dithionite; sodium hydrogencarbonate / water / 3.5 h / 20 - 35 °C 3.1: diethyl ether View Scheme
参考文献
Lu, Xiaoyun; Liu, Xiaobo; Wan, Baojie; Franzblau, Scott G.; Chen, Lili; Zhou, Changlin; You, Qidong
European Journal of Medicinal Chemistry, 2012 , vol. 49, p. 164 - 171
反应条件
in methanol T=35°C; 120 h;
参考文献
Meester, Johan W. G. De; Plas, Henk C. van der; Middelhoven, Wouter J.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 441 - 451
反应条件
N-ethyl-N,N-diisopropylamine in toluene
T=100°C; 5 h;
参考文献
Poulsen, Thomas B.; Dickmeiss, Gustav; Overgaard, Jacob; Jorgensen, Karl Anker
Angewandte Chemie - International Edition, 2008 , vol. 47, # 25 p. 4687 - 4690
反应条件
1: 83 percent / methanol / 120 h / 35 °C
2: 89 percent / NH3(l) / 3 h / -33 °C
3: 89 percent / Na2S2O4 / H2O / 24 h / Heating
4: 32 percent / acetic anhydride / 2 h / Heating
5: 87 percent / xanthine oxidase (AXO) / 120 h / 4N NaOH, potassium phosphate buffer, pH 8.0
View Scheme
参考文献
Meester, Johan W. G. De; Plas, Henk C. van der; Middelhoven, Wouter J.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 441 - 451
