Yang, Qiang; Ulysse, Luckner G.; McLaws, Mark D.; Keefe, Daniel K.; Haney, Brian P.; Zha, Congxiang; Guzzo, Peter R.; Liu, Shuang
Organic Process Research and Development, 2012 , vol. 16, # 3 p. 499 - 506
1: tetrahydrofuran; dichloromethane
2: phosphoric acid / 160 °C
3: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / 30 h / 85 °C / Large scale reaction
View Scheme
参考文献
Yang, Qiang; Ulysse, Luckner G.; McLaws, Mark D.; Keefe, Daniel K.; Haney, Brian P.; Zha, Congxiang; Guzzo, Peter R.; Liu, Shuang
Organic Process Research and Development, 2012 , vol. 16, # 3 p. 499 - 506
1: (4-bromophenyl)acetyl chloride With pyridine; Si((CH2)3Si[(CH2)3SiMe2(C6H4-4)CH2OH]3)4 in tetrahydrofuran
T=20°C; Acylation;
2: p-methylphenylboronic acid With tetrakis(triphenylphosphine) palladium(0); sodium carbonate in N,N-dimethyl-formamide
T=100°C; Suzuki coupling;
3: With sodium hydroxide in tetrahydrofuran; methanol
Hydrolysis; Further stages.;
参考文献
Hovestad, Neldes J.; Ford, Allan; Jastrzebski, Johann T. B. H.; Van Koten, Gerard
Journal of Organic Chemistry, 2000 , vol. 65, # 20 p. 6338 - 6344
Fontes, Ernest; Lee, Wah Keat; Heiney, Paul A.; Nounesis, George; Garland, Carl W.; et al.
Journal of Chemical Physics, 1990 , vol. 92, # 6 p. 3917 - 3929
