反式-1-(3-氯苯基)-2-硝基乙烯合成路线 （共 10 条）
反应条件
ammonium acetate; acetic acid 6 h; Inert atmosphereSchlenk techniqueReflux;
参考文献
Park, Jung-Eun; Song, Chiman; Choi, Keehyun; Sim, Taebo; Moon, Bongjin; Roh, Eun Joo
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 20 p. 5515 - 5518
反应条件
ammonium acetate in nitromethane; acetic acid
参考文献
Abbott Laboratories
Patent: US5248677 A1, 1993 ;
反应条件
methanesulfonyl chloride; triethylamine in dichloromethane T=0 - 20°C;
参考文献
Taylor, Edward C.; Liu, Bin
Journal of Organic Chemistry, 2003 , vol. 68, # 26 p. 9938 - 9947
反应条件
ammonium acetate in acetic acid T=60 - 65°C; Cyclization; condensation; nitration; 6 h; sonicated;
参考文献
Taylor, Edward C.; Liu, Bin; Wang, Wei
Journal of Organic Chemistry, 2000 , vol. 65, # 15 p. 4750 - 4752
反应条件
ammonium acetate in acetic acid T=60 - 65°C; Cyclization; condensation; nitration; 6 h; sonicated;
参考文献
Taylor, Edward C.; Liu, Bin; Wang, Wei
Journal of Organic Chemistry, 2000 , vol. 65, # 15 p. 4750 - 4752
反应条件
palladium (II) trifluoroacetate; silver(I) acetate in ethylene glycol dimethyl ether; dimethyl sulfoxide T=100°C; 24 h; GloveboxSchlenk techniqueInert atmosphere; Overall yield = 47 percent; regioselective reaction;
参考文献
Zhang, Min; Hu, Peng; Zhou, Jun; Wu, Ge; Huang, Shijun; Su, Weiping
Organic Letters, 2013 , vol. 15, # 7 p. 1718 - 1721
反应条件
1: aq. NaOH / ethanol / 65 h / 38 °C 2: CH3SO2Cl; Et3N / CH2Cl2 / 0 - 20 °C View Scheme
参考文献
Taylor, Edward C.; Liu, Bin
Journal of Organic Chemistry, 2003 , vol. 68, # 26 p. 9938 - 9947
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
参考文献
Hocquaux; Marcot; Redeuilh; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 319 - 329
反应条件
1: 41 percent / LiAlH4 / tetrahydrofuran
2: 39 percent / triethylamine / diethyl ether / 1 h / Ambient temperature
View Scheme
参考文献
Hocquaux; Marcot; Redeuilh; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 319 - 329
反应条件
1: 41 percent / LiAlH4 / tetrahydrofuran
2: 39 percent / triethylamine / diethyl ether / 1 h / Ambient temperature
3: 63 percent / dimethylformamide / 24 h / 100 °C
4: 55 percent / polyphosphoric acid / 2 h / 145 °C
View Scheme
参考文献
Hocquaux; Marcot; Redeuilh; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 319 - 329
