(S)-(-)-1-苯丙胺合成路线 （共 55 条）
反应条件
sodium tetrahydroborate; (S)-valinol; zirconium tetrachloride in tetrahydrofuran Ambient temperature; Title compound not separated from byproducts;
参考文献
Itsuno, Shinichi; Sakurai, Yoshiki; Shimizu, Koji; Ito, Koichi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 7 p. 1859 - 1863
反应条件
glucose dehydrogenase; (R)-alanine; D-glucose; ω-transaminase ATA-117; pyridoxal 5'-phosphate; β-NADP+; lactate dehydrogenase in dimethyl sulfoxide T=30°C; pH=7; 24 h; aq. phosphate bufferEnzymatic reaction; optical yield given as percent eestereoselective reaction;
参考文献
Koszelewski, Dominik; Lavandera, Ivan; Clay, Dorina; Rozzell, David; Kroutil, Wolfgang
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 17 p. 2761 - 2766
反应条件
hydrogenchloride; zinc in ethanol T=55 - 60°C; 24 h;
参考文献
El-Shehawy, Ashraf A.
Tetrahedron, 2007 , vol. 63, # 25 p. 5490 - 5500
反应条件
1: in toluene T=50°C; P=600.06 Torr; 0.333333 h; microwave irradiation; 2: With ammonium chloride in toluene 3: With water Further stages. Title compound not separated from byproducts.;
参考文献
Almansa, Raquel; Guijarro, David; Yus, Miguel
Tetrahedron Asymmetry, 2008 , vol. 19, # 11 p. 1376 - 1380
反应条件
1: 43 percent / lipase B from Candida antarctica / diethyl ether / 20 °C / Enzymatic reaction 2: H2 / Ra/Ni View Scheme
参考文献
Messina, Flavia; Botta, Maurizio; Corelli, Federico; Mugnaini, Claudia
Tetrahedron Letters, 1999 , vol. 40, # 40 p. 7289 - 7292
反应条件
1.1: NaH / dimethylformamide / 0 °C 1.2: 82 percent / dimethylformamide / 0 - 20 °C 2.1: BH3*THF; (S)-proline (R)-1,1'-bi(2-naphthyl)dioxyboryl ester / tetrahydrofuran / 48 h / 0 - 5 °C 2.2: aq. HCl / tetrahydrofuran View Scheme
参考文献
Chu, Yunbo; Shan, Zixing; Liu, Dejun; Sun, Nannan
Journal of Organic Chemistry, 2006 , vol. 71, # 10 p. 3998 - 4001
反应条件
1.1: 4-methylmorpholine; isobutyl chloroformate / CH2Cl2 1.2: triethylamine; 2-mercaptopyridine N-oxide / CH2Cl2 / 0.17 h / -20 °C 1.3: 61 percent / t-BuSH / CH2Cl2 / 10 h / Irradiation 2.1: 98 percent / H2 / Pd/C / acetic acid; methanol / 0.17 h / 20 °C View Scheme
参考文献
Kawakami; Ohtake; Arakawa; Okachi; Imada; Murahashi
Bulletin of the Chemical Society of Japan, 2000 , vol. 73, # 11 p. 2423 - 2444
反应条件
1: With hydrogenchloride; water in acetonitrile T=20°C; 10 h; Inert atmosphere; 2: With sodium hydroxide in water; acetonitrile Inert atmosphere; 3: With ammonium cerium (IV) nitrate in water; acetonitrile 1 h; Inert atmosphere;
参考文献
Allef, Petra; Kunz, Horst
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2009 , vol. 64, # 6 p. 646 - 652
反应条件
1: methanol / Heating 2: polystyrene-supported (1S,2R)-PhCH2N(Me)CH(Me)CH(Ph)OH; i-Pr3SiCl / toluene; hexane / 24 h / -10 °C 3: conc. HCl; Zn / ethanol / 24 h / 55 - 60 °C View Scheme
参考文献
Wu, Ming-Jung; Pridgen, Lendon N.
Journal of Organic Chemistry, 1991 , vol. 56, # 3 p. 1340 - 1344
反应条件
1: polystyrene-supported (1S,2R)-PhCH2N(Me)CH(Me)CH(Ph)OH; i-Pr3SiCl / toluene; hexane / 24 h / -10 °C 2: conc. HCl; Zn / ethanol / 24 h / 55 - 60 °C View Scheme
参考文献
El-Shehawy, Ashraf A.
Tetrahedron Asymmetry, 2006 , vol. 17, # 18 p. 2617 - 2624
