(S)-(-)-1-苯丙胺合成路线 （共 55 条）
反应条件
1: recombinant ω-transaminase from Burkholderia vietnamiensis G4; pyridoxal 5'-phosphate / aq. phosphate buffer / 12 h / 37 °C / pH 7.4 / |Enzymatic reaction 2: recombinant ω-transaminase from Burkholderia vietnamiensis G4; pyridoxal 5'-phosphate / aq. phosphate buffer / 0.08 h / 37 °C / pH 7.4 / |Enzymatic reaction View Scheme
参考文献
Jiang, Jinju; Chen, Xi; Feng, Jinhui; Wu, Qiaqing; Zhu, Dunming
Journal of Molecular Catalysis B: Enzymatic, 2014 , vol. 100, p. 32 - 39
反应条件
1: recombinant ω-transaminase from Burkholderia vietnamiensis G4; pyridoxal 5'-phosphate / aq. phosphate buffer / 0.08 h / 37 °C / pH 7.4 / |Enzymatic reaction 2: recombinant ω-transaminase from Burkholderia vietnamiensis G4; pyridoxal 5'-phosphate / aq. phosphate buffer / 12 h / 37 °C / pH 7.4 / |Enzymatic reaction 3: recombinant ω-transaminase from Burkholderia vietnamiensis G4; pyridoxal 5'-phosphate / aq. phosphate buffer / 0.08 h / 37 °C / pH 7.4 / |Enzymatic reaction View Scheme
参考文献
Jiang, Jinju; Chen, Xi; Feng, Jinhui; Wu, Qiaqing; Zhu, Dunming
Journal of Molecular Catalysis B: Enzymatic, 2014 , vol. 100, p. 32 - 39
反应条件
hydrogenchloride; sodium hydroxide 1.) methanol, room temperature; Multistep reaction;
参考文献
Guijarro, David; Pinho, Pedro; Andersson, Pher G.
Journal of Organic Chemistry, 1998 , vol. 63, # 8 p. 2530 - 2535
反应条件
1: 1.) n-BuLi / 1.) THF, -78 deg C, 2.) -100 deg C View Scheme
参考文献
Gawley, Robert E.; Rein, Kathleen; Chemburkar, Sanjay
Journal of Organic Chemistry, 1989 , vol. 54, # 13 p. 3002 - 3004
反应条件
N,N'-dimethyl-N,N'-propyleneurea T=-20°C; 24 h; Title compound not separated from byproducts;
参考文献
Sabot, Cyrille; Subhash, Pithani V.; Valleix, Alain; Arseniyadis, Stellios; Mioskowski, Charles
Synlett, 2008 , # 2 p. 268 - 272
反应条件
oxonium Title compound not separated from byproducts;
参考文献
Zhang, Xiaomei; Gong, Liuzhu; Mi, Aiqiao; Cui, Xin; Jiang, Yaozhong; C. K. Choi, Michael; S. C. Chan, Albert
Tetrahedron Letters, 2001 , vol. 42, # 36 p. 6369 - 6372
反应条件
(S)-selective ω-transaminase from Ochrobactrum anthropi; L-threonine deaminase from Escherichia coli; pyridoxal 5'-phosphate T=37°C; pH=7.5; 28 h; aq. phosphate bufferResolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Malik, M. Shaheer; Park, Eul-Soo; Shin, Jong-Shik
Green Chemistry, 2012 , vol. 14, # 8 p. 2137 - 2140
反应条件
Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Fernandez, Elena; Hooper, Mark W.; Knight, Frances I.; Brown, John M.
Chemical Communications, 1997 , # 2 p. 173 - 174
反应条件
Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Gawley, Robert E.; Rein, Kathleen; Chemburkar, Sanjay
Journal of Organic Chemistry, 1989 , vol. 54, # 13 p. 3002 - 3004
反应条件
lithium aluminium tetrahydride; 3-O-cyclohexylmethyl-1,2-O-cyclohexylidene-α-D-glucofuranose in diethyl ether 2.5 h; HeatingLiAlH4 concentration effect on enantiomeric excess; asymmetric reduction of ketones and isoelectronic ketone oximes with LiAlH4-3-O-cyclohexylmethyl-1,2-O-cyclohexylidene-α-D-glucofuranose complex; Product distribution;
参考文献
Landor, Stephen R.; Chan, Yuet M.; Sonola, Olutunji O.; Tatchell, Austin R.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 3 p. 493 - 496
