2,2,2-三氟-1,1-双(4-甲氧基苯基)乙醇合成路线 （共 7 条）
反应条件
1: C9H16N2*C3H2F6O2 With potassium tert-butylate; tetrabutyl-ammonium chloride in N,N-dimethyl-formamide
T=-30°C; 0.5 h;
2: 1,1-di(p-methoxyphenyl)-ketone in N,N-dimethyl-formamide
T=-30°C; 1.5 h;
参考文献
Riofski, Mark V.; Hart, Allison D.; Colby, David A.
Organic Letters, 2013 , vol. 15, # 1 p. 208 - 211
反应条件
1: 2,2,2-trifluoroethane-1,1-diol With potassium tert-butylate in N,N-dimethyl-formamide
T=-50°C; 0.583333 h;
2: 1,1-di(p-methoxyphenyl)-ketone in N,N-dimethyl-formamide
T=-50°C; 1 h;
参考文献
Surya Prakash; Zhang, Zhe; Wang, Fang; Munoz, Socrates; Olah, George A.
Journal of Organic Chemistry, 2013 , vol. 78, # 7 p. 3300 - 3305
参考文献
Kaluszyner et al.
Journal of the American Chemical Society, 1955 , vol. 77, p. 4164,4167
反应条件
1: tetramethylammonium fluoride / tetrahydrofuran / a) O deg C, 30 min, b) 25 deg C, 16 h
2: 10percent aq.HF / tetrahydrofuran / 5 h
View Scheme
参考文献
Ahvazi, Behzad C.; Argyropoulos, Dimitris S.
Journal of Agricultural and Food Chemistry, 1996 , vol. 44, # 8 p. 2167 - 2175
反应条件
in diethyl ether
Grignard reaction; ice-bath temperature;
参考文献
Fujio, Mizue; Morimoto, Hiroshi; Kim, Hyun-Joong; Tsuno, Yuho
Bulletin of the Chemical Society of Japan, 1997 , vol. 70, # 6 p. 1403 - 1411
反应条件
ethanol; water
T=25°C; Hydrolysis; Solvolysis; Kinetics;
参考文献
Fujio, Mizue; Kim, Hyun-Joong; Morimoto, Hiroshi; Yoh, Soo-Dong; Tsuno, Yuho
Journal of Physical Organic Chemistry, 1999 , vol. 12, # 11 p. 843 - 857
反应条件
phosphorus; iodine; acetic acid
Reagens 4: H2O;
参考文献
Kaluszyner et al.
Journal of the American Chemical Society, 1955 , vol. 77, p. 4164,4167
