3-氯-4-甲氧基苯甲酸甲酯合成路线 （共 22 条）
反应条件
potassium carbonate in water; N,N-dimethyl-formamide
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1223170 A1, 2002 ;
反应条件
in toluene T=200°C; 16 h; Inert atmosphere;
参考文献
Lee, Jennifer J.; Kraus, George A.
Tetrahedron Letters, 2013 , vol. 54, # 19 p. 2366 - 2368
反应条件
Oxonereg;; potassium chloride in water; acetonitrile T=20°C;
参考文献
Tamhankar; Desai; Mane; Wadgaonkar; Bedekar
Synthetic Communications, 2001 , vol. 31, # 13 p. 2021 - 2027
反应条件
sodium hydroxide in water
参考文献
Smith Kline
Patent: US3975537 A1, 1976 ;
反应条件
sodium hypochlorite in acetic acid T=0 - 25°C; 1 h;
参考文献
Stevens, Robert V.; Chapman, Kevin T.; Stubbs, Cheryl A.; Tam, Weyton W.; Albizati, Kim F.
Tetrahedron Letters, 1982 , vol. 23, # 45 p. 4647 - 4650
反应条件
acetyl chloride T=0 - 20°C; 15 h;
参考文献
El-Gamal, Mohammed I.; Choi, Hong Seok; Yoo, Kyung Ho; Baek, Daejin; Oh, Chang-Hyun
Chemical Biology and Drug Design, 2013 , vol. 82, # 3 p. 336 - 347
反应条件
Oxonereg;; sodium bromide in water T=20°C; 24 h;
参考文献
Koo, Bon-Suk; Kim, Eun-Hoo; Lee, Kee-Jung
Synthetic Communications, 2002 , vol. 32, # 15 p. 2275 - 2286
反应条件
1: 93 percent / concd. H2SO4 / 5 h / Heating 2: K2CO3 / acetone / 16 h / Heating View Scheme
参考文献
Riggs; Nichols; Foreman; Truex
Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1887 - 1891
反应条件
potassium carbonate in acetone 16 h; Heating;
参考文献
Riggs; Nichols; Foreman; Truex
Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1887 - 1891
反应条件
1: methanol; N,N,N',N',N'',N''-hexamethylphosphoric triamide / 15 h / 120 °C 2: acetyl chloride / 0 - 20 °C View Scheme
参考文献
El-Gamal, Mohammed I.; Choi, Hong Seok; Yoo, Kyung Ho; Baek, Daejin; Oh, Chang-Hyun
Chemical Biology and Drug Design, 2013 , vol. 82, # 3 p. 336 - 347
