3-氯-4-甲氧基苯甲酸甲酯合成路线 （共 22 条）
反应条件
potassium carbonate in acetone Heating;
参考文献
Mehta; Musso
Journal of Pharmaceutical Sciences, 1986 , vol. 75, # 4 p. 410 - 412
参考文献
Sorensen
Analytical Chemistry, 1955 , vol. 27, p. 388
反应条件
1: 1) KHMDS, 2) trisyl azide / 1) THF, toluene, -78 deg C, 20 min, 2) THF, toluene, -78 deg C, 2 min 2: 1) LiOH, H2O2, 2) PTSA*H2O / 1) THF, H2O, 0 deg C, 0.5 - 1 h, 2) reflux, overnight View Scheme
参考文献
Pearson, Anthony J.; Zhang, Penglie
Journal of Organic Chemistry, 1996 , vol. 61, # 26 p. 9603 - 9604
反应条件
lithium hydroxide; dihydrogen peroxide; toluene-4-sulfonic acid 1) THF, H2O, 0 deg C, 0.5 - 1 h, 2) reflux, overnight; Multistep reaction;
参考文献
Pearson, Anthony J.; Zhang, Penglie
Journal of Organic Chemistry, 1996 , vol. 61, # 26 p. 9603 - 9604
反应条件
1: water; alcohol; aluminium amalgam 2: durch Austausch der Aminogruppe gegen Chlor nach Sandmeyer View Scheme
参考文献
Auwers
Chemische Berichte, 1897 , vol. 30, p. 1477
反应条件
durch Austausch der Aminogruppe gegen Chlor nach Sandmeyer;
参考文献
Auwers
Chemische Berichte, 1897 , vol. 30, p. 1477
反应条件
sodium hydroxide Heating;
参考文献
Riggs; Nichols; Foreman; Truex
Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1887 - 1891
反应条件
hydrogenchloride in tetrahydrofuran
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1223170 A1, 2002 ;
反应条件
1: KOH / methanol 2: thionyl chloride 3: aq.ammonia 4: thionyl chloride View Scheme
参考文献
Mehta; Musso
Journal of Pharmaceutical Sciences, 1986 , vol. 75, # 4 p. 410 - 412
反应条件
1: 98 percent / LiAlH4 / diethyl ether / 1 h / 20 °C 2: 99 percent / PCC; molecular sieves 4 Angstroem / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Riggs; Nichols; Foreman; Truex
Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1887 - 1891
