5,7-二甲氧基-4(3H)-喹唑啉酮合成路线 （共 8 条）
反应条件
in N,N-dimethyl-formamide
T=25 - 90°C; 5.5 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2007/71963 A2, 2007 ;
Location in patent: Page/Page column 59 ;
WO 2007/071963 A2
反应条件
in 2-methoxy-ethanol
2 h; Heating;
参考文献
Hennequin, Laurent F.; Allen, Jack; Breed, Jason; Curwen, Jon; Fennell, Michael; Green, Tim P.; Lambert-Van Der Brempt, Christine; Morgentin, Remy; Norman, Richard A.; Olivier, Annie; Otterbein, Ludovic; Ple, Patrick A.; Warin, Nicolas; Costello, Gerard
Journal of Medicinal Chemistry, 2006 , vol. 49, # 22 p. 6465 - 6488
反应条件
1: 95 percent / ethanol; CH2Cl2 / 0 °C
2: 94 percent / 2-methoxy-ethanol / 2 h / Heating
View Scheme
参考文献
Hennequin, Laurent F.; Allen, Jack; Breed, Jason; Curwen, Jon; Fennell, Michael; Green, Tim P.; Lambert-Van Der Brempt, Christine; Morgentin, Remy; Norman, Richard A.; Olivier, Annie; Otterbein, Ludovic; Ple, Patrick A.; Warin, Nicolas; Costello, Gerard
Journal of Medicinal Chemistry, 2006 , vol. 49, # 22 p. 6465 - 6488
反应条件
N-ethyl-N,N-diisopropylamine; trichlorophosphate in acetonitrile
2 h; Heating / reflux;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/67391 A1, 2006 ;
Location in patent: Page/Page column 49-50 ;
WO 2006/067391 A1
反应条件
pyridine; magnesium bromide
1.5 h; Heating;
参考文献
Hennequin, Laurent F.; Allen, Jack; Breed, Jason; Curwen, Jon; Fennell, Michael; Green, Tim P.; Lambert-Van Der Brempt, Christine; Morgentin, Remy; Norman, Richard A.; Olivier, Annie; Otterbein, Ludovic; Ple, Patrick A.; Warin, Nicolas; Costello, Gerard
Journal of Medicinal Chemistry, 2006 , vol. 49, # 22 p. 6465 - 6488
反应条件
pyridine; magnesium bromide in water; acetic acid
参考文献
AstraZeneca AB
Patent: EP1292594 B1, 2004 ;
反应条件
1.1: 98 percent / MgBr2; pyridine / 1.5 h / Heating
2.1: NaH / dimethylformamide / 1 h / 20 °C
2.2: 83 percent / dimethylformamide / 1 h / 0 °C
3.1: 88 percent / PPh3; DTAD / CH2Cl2 / 1 h / 20 °C
4.1: 100 percent / K2CO3; PhSH / 1-methyl-pyrrolidin-2-one / 0.58 h / 195 °C
5.1: 57 percent / pyridine / 2 h / 120 °C
6.1: 66 percent / PPh3; CCl4 / 1,2-dichloro-ethane / 2 h / 70 °C
7.1: 78 percent / NH3 / methanol / 2 h / 20 °C
View Scheme
参考文献
Hennequin, Laurent F.; Allen, Jack; Breed, Jason; Curwen, Jon; Fennell, Michael; Green, Tim P.; Lambert-Van Der Brempt, Christine; Morgentin, Remy; Norman, Richard A.; Olivier, Annie; Otterbein, Ludovic; Ple, Patrick A.; Warin, Nicolas; Costello, Gerard
Journal of Medicinal Chemistry, 2006 , vol. 49, # 22 p. 6465 - 6488
反应条件
pyridine; magnesium bromide in water; acetic acid
参考文献
AstraZeneca AB
Patent: EP1292594 B1, 2004 ;
