7-氟-5-((四氢-2H-吡喃-4-基)氧基)喹唑啉-4(3h)-酮合成路线 （共 3 条）
反应条件
1: 4-hydroxytetrahydro-4H-pyran With sodium hydride in DMF (N,N-dimethyl-formamide)
T=20°C; 0.25 h;
2: 5,7-difluoroquinazolin-4(3H)-one in DMF (N,N-dimethyl-formamide)
T=20°C; 0.5 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/56801 A1, 2004 ;
Location in patent: Page 57 ;
WO 2004/056801 A1
反应条件
1: 4-hydroxytetrahydro-4H-pyran With sodium hydride in DMF (N,N-dimethyl-formamide)
T=5 - 20°C; 0.25 h;
2: 5,7-difluoroquinazolin-4(3H)-one T=20°C; 0.5 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/41829 A1, 2004 ;
Location in patent: Page 94-95 ;
WO 2004/041829 A1
反应条件
1: With Sodium hydride in DMF (N,N-dimethyl-formamide)
T=20°C; 0.25 h;
2: With 5,7-difluoroquinazolin-4(3H)-one
T=20°C; 0.5 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/56812 A1, 2004 ;
Location in patent: Page 55 ;
WO 2004/056812 A1
