(5-氯-1,3-苯并二恶茂-4-基)氨基甲酸叔丁酯合成路线 （共 3 条）
反应条件
diphenyl phosphoryl azide; triethylamine in 1,4-dioxane T=100°C; Curtius rearrangement; 4 h;
参考文献
Ple, Patrick A.; Green, Tim P.; Hennequin, Laurent F.; Curwen, Jon; Fennell, Michael; Allen, Jack; Lambert-Van Der Brempt, Christine; Costello, Gerard
Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 871 - 887
反应条件
1.1: LDA / tetrahydrofuran / 0.5 h / -78 °C 1.2: 84 percent / tetrahydrofuran / -78 - 20 °C 2.1: 81 percent / diphenoxyphosphoryl azide; Et3N / dioxane / 4 h / 100 °C View Scheme
参考文献
Ple, Patrick A.; Green, Tim P.; Hennequin, Laurent F.; Curwen, Jon; Fennell, Michael; Allen, Jack; Lambert-Van Der Brempt, Christine; Costello, Gerard
Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 871 - 887
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 3 h;
参考文献
Ple, Patrick A.; Green, Tim P.; Hennequin, Laurent F.; Curwen, Jon; Fennell, Michael; Allen, Jack; Lambert-Van Der Brempt, Christine; Costello, Gerard
Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 871 - 887
