lithium hydroxide hydrate in tetrahydrofuran; methanol; water T=20°C; 1 h; Inert atmosphere;

1: isopropyl alcohol With sodium hydride in tetrahydrofuran; mineral oil T=0°C; 0.25 h; Inert atmosphere; 2: 3-fluoro-4-nitro-benzoic acid in tetrahydrofuran; mineral oil T=0 - 25°C; 2 h; Inert atmosphere;

1.1: potassium carbonate / N,N-dimethyl-formamide / 70 °C 2.1: lithium hydroxide hydrate / tetrahydrofuran; water / 0 - 20 °C 2.2: 0 °C View Scheme

1.1: thionyl chloride / 12 h / 0 °C / Reflux; Inert atmosphere 2.1: triphenylphosphine / tetrahydrofuran / 0.03 h / 20 °C / Inert atmosphere 2.2: 16 h / Inert atmosphere 3.1: lithium hydroxide hydrate / tetrahydrofuran; methanol; water / 1 h / 20 °C / Inert atmosphere View Scheme

ethanol Erwaermen des Reaktionsprodukts mit aethanol. KOH;