9-氟-11,17-二羟基-16alpha-甲基-3-氧代雄甾-1,4-二烯-17-羧酸合成路线 （共 5 条）
反应条件
1: With oxygen; potassium carbonate in methanol
T=20°C; 18 h;
2: With hydrogenchloride in water
参考文献
PFIZER LIMITED; GLOSSOP, Paul Alan; MILLAN, David Simon; PRICE, David Anthony
Patent: WO2010/136940 A1, 2010 ;
Location in patent: Page/Page column 64 ;
WO 2010/136940 A1
反应条件
1: With copper diacetate; air
1.5 h;
2: With sodium chlorite; potassium dihydrogenphosphate; 2-methyl-but-2-ene in tetrahydrofuran; water; tert-butyl alcohol
T=25 - 40°C; 16 h;
参考文献
Conrow, Raymond E.; Dillow, Glen W.; Bian, Liangqiao; Xue, Liang; Papadopoulou, Olga; Baker, John K.; Scott, Britt S.
Journal of Organic Chemistry, 2002 , vol. 67, # 19 p. 6835 - 6836
反应条件
in various solvent(s)
pH=9.2; Product distribution; Further Variations:pH-values;
参考文献
Edmonds, John S.; Morita, Masatoshi; Turner, Peter; Skelton, Brian W.; White, Allan H.
Steroids, 2006 , vol. 71, # 1 p. 34 - 41
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
T=20°C; Substitution;
参考文献
Lin, Hening; Abida, Wassim M.; Sauer, Robert T.; Cornish, Virginia W.
Journal of the American Chemical Society, 2000 , vol. 122, # 17 p. 4247 - 4248
反应条件
1: 90 percent / diisopropylethylamine / dimethylformamide / 20 °C
2: 80 percent / tri-n-butylphosphine / dimethylformamide; H2O / 20 °C
View Scheme
参考文献
Lin, Hening; Abida, Wassim M.; Sauer, Robert T.; Cornish, Virginia W.
Journal of the American Chemical Society, 2000 , vol. 122, # 17 p. 4247 - 4248
