5-甲基-3,4-二苯基-异噁唑合成路线 （共 19 条）
反应条件
1: triethylamine / dichloromethane / 5 - 35 °C / Large scale reaction 2: hydrogenchloride / water / 98 - 102 °C / Large scale reaction View Scheme
参考文献
Reddy, Anumula Raghupathi; Goverdhan, Gilla; Sampath, Aalla; Mukkanti, Khagga; Reddy, Padi Pratap; Bandichhor, Rakeshwar
Synthetic Communications, 2012 , vol. 42, # 5 p. 639 - 649
反应条件
sulfuric acid; sulfur trioxide T=5 - 25°C; 1.33333 h;
参考文献
Reddy, Anumula Raghupathi; Goverdhan, Gilla; Sampath, Aalla; Mukkanti, Khagga; Reddy, Padi Pratap; Bandichhor, Rakeshwar
Synthetic Communications, 2012 , vol. 42, # 5 p. 639 - 649
反应条件
1: With chlorosulfonic acid T=0°C; 2 h; 2: With ammonium hydroxide T=0°C; 2 h;
参考文献
Di Nunno, Leonardo; Vitale, Paola; Scilimati, Antonio; Tacconelli, Stefania; Patrignani, Paola
Journal of Medicinal Chemistry, 2004 , vol. 47, # 20 p. 4881 - 4890
反应条件
1: With chlorosulfonic acid in dichloromethane T=0°C; Reflux; 2: With ammonia in dichloromethane; water T=25 - 35°C; 1 h;
参考文献
Reddy, Anumula Raghupathi; Goverdhan, Gilla; Sampath, Aalla; Mukkanti, Khagga; Reddy, Padi Pratap; Bandichhor, Rakeshwar
Synthetic Communications, 2012 , vol. 42, # 5 p. 639 - 649
反应条件
chlorosulfonic acid in dichloromethane
RefluxLarge scale reaction;
参考文献
Reddy, Anumula Raghupathi; Goverdhan, Gilla; Sampath, Aalla; Mukkanti, Khagga; Reddy, Padi Pratap; Bandichhor, Rakeshwar
Synthetic Communications, 2012 , vol. 42, # 5 p. 639 - 649
反应条件
in dichloromethane
T=20°C; 12 h; Heating / reflux;
参考文献
RICHTER GEDEON VEGYESZETI GYAR RT.
Patent: WO2005/7620 A2, 2005 ;
Location in patent: Page/Page column 15-16 ;
反应条件
chlorosulfonic acid
T=20°C; 5 h;
参考文献
Erdelyi, Peter; Fodor, Tamas; Varga, Agnes Kis; Czugler, Matyas; Gere, Aniko; Fischer, Janos
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 9 p. 5322 - 5330
反应条件
chlorosulfonic acid; trifluoroacetic acid
T=3 - 60°C; 2.2 h; Product distribution / selectivity;
参考文献
PHARMACIA CORPORATION?
Patent: WO2005/123701 A1, 2005 ;
Location in patent: Page/Page column 37-38 ;
反应条件
chlorosulfonic acid in dichloromethane
T=0°C; Reflux;
参考文献
Reddy, Anumula Raghupathi; Goverdhan, Gilla; Sampath, Aalla; Mukkanti, Khagga; Reddy, Padi Pratap; Bandichhor, Rakeshwar
Synthetic Communications, 2012 , vol. 42, # 5 p. 639 - 649
