5-苯基-1,2,4-噁二唑-3-羧酸合成路线 （共 5 条）
反应条件
lithium hydroxide hydrate in tetrahydrofuran; methanol; water
T=20°C; 3 h;
参考文献
ChemoCentryx, Inc.; Fan, Junfa; Krasinski, Antoni; Lange, Christopher W.; Lui, Rebecca M.; McMahon, Jeffrey P.; Powers, Jay P.; Zeng, Yibin; Zhang, Penglie
Patent: US2014/154179 A1, 2014 ;
Location in patent: Paragraph 0429; 0432 ;
反应条件
1: With lithium hydroxide hydrate in tetrahydrofuran; water
2: With hydrogenchloride in tetrahydrofuran; water
T=20°C; pH=2; 1 h;
参考文献
Huguet, Florian; Melet, Armelle; Alves de Sousa, Rodolphe; Lieutaud, Aurelie; Chevalier, Jacqueline; Maigre, Laure; Deschamps, Patrick; Tomas, Alain; Leulliot, Nicolas; Pages, Jean-Marie; Artaud, Isabelle
ChemMedChem, 2012 , vol. 7, # 6 p. 1020 - 1030
反应条件
1: K2CO3 / acetone
2: Heating
3: KOH / methanol
View Scheme
参考文献
Strani,G.; Garau,A.M.
Gazzetta Chimica Italiana, 1963 , vol. 93, p. 482 - 492
反应条件
1.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 °C
2.1: lithium hydroxide hydrate / tetrahydrofuran; water
2.2: 1 h / 20 °C / pH 2
View Scheme
参考文献
Huguet, Florian; Melet, Armelle; Alves de Sousa, Rodolphe; Lieutaud, Aurelie; Chevalier, Jacqueline; Maigre, Laure; Deschamps, Patrick; Tomas, Alain; Leulliot, Nicolas; Pages, Jean-Marie; Artaud, Isabelle
ChemMedChem, 2012 , vol. 7, # 6 p. 1020 - 1030
参考文献
Ponzio
Gazzetta Chimica Italiana, 1932 , vol. 62, p. 415,419
