反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 110 °C
2.1: boron tribromide / dichloromethane / -78 - 20 °C
2.2: Cooling with ice
3.1: potassium tert-butylate / N,N-dimethyl-formamide / 3 h / 120 °C
View Scheme
参考文献
MERCK SHARP and DOHME CORP.; COBURN, Craig A.; WU, Hao; HU, Bin; ZHONG, Bin; WANG, Dahai; XU, Zaixu; SUN, Fei; JI, Tao; DAN, Zhigang
Patent: WO2012/3642 A1, 2012 ;