5,6,8,9-四氢-苯并环庚烯-7-酮合成路线 （共 22 条）
反应条件
sulfuric acid; nitric acid in nitromethane; water
T=0°C; 3.16667 h;
参考文献
RIGEL PHARMACEUTICALS, INC.; SINGH, Rajinder; HECKRODT, Thilo, J.; HOLLAND, Sacha
Patent: WO2010/5876 A2, 2010 ;
Location in patent: Page/Page column 56 ;
WO 2010/005876 A2
反应条件
1: With N-bromosuccinmide; trimethylsilyl trifluoromethanesulfonate in acetonitrile
T=20°C; 4.5 h;
2: With 1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile
T=20°C; 0.5 h;
参考文献
Albrecht, Sebastien; Al-Lakkis-Wehbe, Mira; Orsini, Alban; Defoin, Albert; Pale, Patrick; Salomon, Emmanuel; Tarnus, Celine; Weibel, Jean-Marc
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 4 p. 1434 - 1449
