N-(2-苯基乙基)-4-哌啶甲酰胺合成路线 （共 7 条）
反应条件
hydrogenchloride in water; ethyl acetate
T=20°C; 2 h;
参考文献
Hu, Suwen; Gu, Quan; Wang, Zhilong; Weng, Zhiyong; Cai, Yunrui; Dong, Xiaowu; Hu, Yongzhou; Liu, Tao; Xie, Xin
European Journal of Medicinal Chemistry, 2014 , vol. 71, p. 259 - 266
反应条件
trifluoroacetic acid in dichloromethane
T=20°C; 2.5 h;
参考文献
Luo; Williams; Read; Curran
Journal of Organic Chemistry, 2001 , vol. 66, # 12 p. 4261 - 4266
反应条件
1: 87 percent / triethylamine / tetrahydrofuran; H2O / 20 °C
2: 81 percent / EDCI; HOBt; Et3N / CHCl3; dimethylformamide / 16 h / 20 °C
3: TFA / CH2Cl2 / 2.5 h / 20 °C
View Scheme
参考文献
Luo; Williams; Read; Curran
Journal of Organic Chemistry, 2001 , vol. 66, # 12 p. 4261 - 4266
反应条件
1: 81 percent / EDCI; HOBt; Et3N / CHCl3; dimethylformamide / 16 h / 20 °C
2: TFA / CH2Cl2 / 2.5 h / 20 °C
View Scheme
参考文献
Luo; Williams; Read; Curran
Journal of Organic Chemistry, 2001 , vol. 66, # 12 p. 4261 - 4266
反应条件
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 18 h / 20 °C
2: hydrogenchloride / ethyl acetate; water / 2 h / 20 °C
View Scheme
参考文献
Hu, Suwen; Gu, Quan; Wang, Zhilong; Weng, Zhiyong; Cai, Yunrui; Dong, Xiaowu; Hu, Yongzhou; Liu, Tao; Xie, Xin
European Journal of Medicinal Chemistry, 2014 , vol. 71, p. 259 - 266
反应条件
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 18 h / 20 °C
2: hydrogenchloride / ethyl acetate; water / 2 h / 20 °C
View Scheme
参考文献
Hu, Suwen; Gu, Quan; Wang, Zhilong; Weng, Zhiyong; Cai, Yunrui; Dong, Xiaowu; Hu, Yongzhou; Liu, Tao; Xie, Xin
European Journal of Medicinal Chemistry, 2014 , vol. 71, p. 259 - 266
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
T=50°C; 48 h;
参考文献
Luo; Williams; Read; Curran
Journal of Organic Chemistry, 2001 , vol. 66, # 12 p. 4261 - 4266
