2-氨基-4'-氟二苯甲酮合成路线 （共 25 条）
反应条件
hydrogenchloride; iron in ethanol; water 1 h; Reflux;
参考文献
Zhang, Jintang; Yu, Chenmin; Wang, Sujing; Wan, Changfeng; Wang, Zhiyong
Chemical Communications, 2010 , vol. 46, # 29 p. 5244 - 5246
反应条件
n-butyllithium in tetrahydrofuran; hexane T=-78°C; Inert atmosphere;
参考文献
Acker, Timothy M.; Khatri, Alpa; Vance, Katie M.; Slabber, Cathryn; Bacsa, John; Snyder, James P.; Traynelis, Stephen F.; Liotta, Dennis C.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 16 p. 6434 - 6456
反应条件
Nalco silica sol 1060 in diethyl ether; hexane; ethyl acetate
参考文献
US5506219 A1, ;
US 5506219 A
反应条件
sulfuric acid Yield given;
参考文献
Tetrahedron Letters, , vol. 34, # 51 p. 8267 - 8270
反应条件
1.1: PCl5 / Heating 1.2: AlCl3 / 0 - 20 °C 2.1: aq. HCl / 1 h / cooling View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 6 p. 1213 - 1221
反应条件
1: PCl5 / 0.5 h / 50 °C 2: AlCl3 / 1 h 3: 86 percent / H2 / 5percent Pd/C / ethanol View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 37, # 1 p. 110 - 115
反应条件
1: AlCl3 / 1 h 2: 86 percent / H2 / 5percent Pd/C / ethanol View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 37, # 1 p. 110 - 115
反应条件
1.1: 79 percent / NaOH / H2O 2.1: PCl5 / Heating 2.2: AlCl3 / 0 - 20 °C 3.1: aq. HCl / 1 h / cooling View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 6 p. 1213 - 1221
反应条件
1: With aluminium trichloride; boron trichloride in toluene; xylene 12 h; Heating; 2: With hydrogenchloride 2 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 22 p. 4702 - 4713
反应条件
1: AlCl3 / 4 h / 80 - 90 °C 2: conc. H2SO4 / 0.25 h / 120 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 11, # 7 p. 1153 - 1160
