2-氨基-4'-氟二苯甲酮合成路线 （共 25 条）
反应条件
1.1: triethylamine / ethanol / 0.17 h 1.2: 2 h / |Reflux 2.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C / |Inert atmosphere View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 56, # 16 p. 6434 - 6456
反应条件
potassium hydroxide; bromine
参考文献
Journal of Organic Chemistry, , vol. 26, p. 2239 - 2242
反应条件
1: NH3 2: Br2, aq. KOH View Scheme
参考文献
Journal of Organic Chemistry, , vol. 26, p. 2239 - 2242
反应条件
1: H2SO4 2: NH3 3: Br2, aq. KOH View Scheme
参考文献
Journal of Organic Chemistry, , vol. 26, p. 2239 - 2242
反应条件
1: 60.4 percent / piperidine / 144 h / 170 °C 2: 80.7 percent / phosphorus oxochloride / 2 h / Heating View Scheme
参考文献
Suzuki; Iwasaki; Fujikawa; Kitahara; Sakashita; Sakoda
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 10 p. 2727 - 2743
反应条件
methanesulfonic acid in isopropyl alcohol T=80 - 87°C; 8 h;
参考文献
SUMIKA FINE CHEMICALS Co., Ltd.; Nissan Chemical Industries, Ltd.
Patent: EP1375487 A1, 2004 ;
Location in patent: Page 5 ;
反应条件
1: 73.9 percent / conc. sulfuric acid / acetic acid / 10 h / 100 °C 2: DIBAL-H / toluene / 2 h / 0 °C 3: 56.5 percent / pyridinium chlorochromate; sodium acetate / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 9, # 10 p. 2727 - 2743
反应条件
1: 73.9 percent / conc. sulfuric acid / acetic acid / 10 h / 100 °C 2: DIBAL-H / toluene / 2 h / 0 °C View Scheme
参考文献
Suzuki; Iwasaki; Fujikawa; Kitahara; Sakashita; Sakoda
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 10 p. 2727 - 2743
反应条件
methanesulfonic acid in benzene 10 h; Heating;
参考文献
Suzuki; Iwasaki; Fujikawa; Kitahara; Sakashita; Sakoda
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 10 p. 2727 - 2743
反应条件
methanesulfonic acid in benzene 10 h; Heatingazeotropic dehydration;
参考文献
Heterocycles, , vol. 50, # 1 p. 479 - 483
