1.1: dichloromethane / 20 °C / Inert atmosphere; Large scale reaction 2.1: dichloromethane / -15 - 0 °C / Inert atmosphere 3.1: sodium hydroxide / methanol; water / 5 - 40 °C / Inert atmosphere; Large scale reaction 3.2: pH 1 - 2 / Inert atmosphere; Large scale reaction 4.1: dichloromethane / 2 h / 20 °C / Inert atmosphere; Large scale reaction 5.1: triethylamine / dichloromethane / -10 °C / Inert atmosphere; Large scale reaction 6.1: methanesulfonic acid; water / 10 h / 70 °C / Inert atmosphere; Large scale reaction 6.2: Inert atmosphere; Large scale reaction View Scheme