1-苄基-1,2,3,6-四氢-4-苯基吡啶合成路线 （共 18 条）
反应条件
1: 1,2-dichloro-ethane / Cooling with ice; Reflux 2: methanol / 2.5 h / Reflux View Scheme
参考文献
Conway, Richard J.; Valant, Celine; Christopoulos, Arthur; Robertson, Alan D.; Capuano, Ben; Crosby, Ian T.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 7 p. 2560 - 2564
反应条件
hydrogen; palladium on activated charcoal in ethanol
参考文献
Sakamuri, Sukumar; Enyedy, Istvan J; Kozikowski, Alan P; Zaman, Wahiduz A; Johnson, Kenneth M; Wang, Shaomeng
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 495 - 500
反应条件
1: hydrogenchloride / diethyl ether; ethyl acetate 2: palladium 10 on activated carbon; hydrogen / ethanol / 44 h View Scheme
参考文献
Conway, Richard J.; Valant, Celine; Christopoulos, Arthur; Robertson, Alan D.; Capuano, Ben; Crosby, Ian T.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 7 p. 2560 - 2564
反应条件
phosphorus pentoxide in toluene
Heating;
参考文献
Sakamuri, Sukumar; Enyedy, Istvan J; Kozikowski, Alan P; Zaman, Wahiduz A; Johnson, Kenneth M; Wang, Shaomeng
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 495 - 500
反应条件
tetrabutyl ammonium fluoride; tris(dibenzylideneacetone)dipalladium(0) chloroform complex in tetrahydrofuran
T=20°C; 18 h;
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2008/79255 A1, 2008 ;
Location in patent: Page/Page column 28-29 ;
反应条件
tetrabutyl ammonium fluoride; biphenyl-2-yl-di-tert-butyl-phosphane; palladium(II) bromide in tetrahydrofuran
T=50°C; 20 h;
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2008/79255 A1, 2008 ;
Location in patent: Page/Page column 28-29 ;
反应条件
sodium triacetoxyborate; acetic acid in anhydrous dichloroethane
T=20°C; 14 h;
参考文献
Meiji Seika Kaisha, Ltd.
Patent: US6355642 B1, 2002 ;
Location in patent: Page column 31 ;
反应条件
[PdCp(η3-C3H5)]; potassium carbonate; phenyldicyclohexylphosphine in tetrahydrofuran; water
T=50°C; 1 h;
参考文献
Tsukamoto, Hirokazu; Kondo, Yoshinori
Angewandte Chemie - International Edition, 2008 , vol. 47, # 26 p. 4851 - 4854
反应条件
[{(η5-C5Me5)IrCl}2(μ-Cl)2]; triethylammonium formate; potassium iodide in dichloromethane
T=40°C; 24 h; Sealed tube; chemoselective reaction;
参考文献
Wu, Jianjun; Tang, Weijun; Pettman, Alan; Xiao, Jianliang
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 1 p. 35 - 40
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
18 - 20 h; Product distribution / selectivity;
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2008/79255 A1, 2008 ;
Location in patent: Page/Page column 20 ;
