1-苄基-1,2,3,6-四氢-4-苯基吡啶合成路线 （共 18 条）
反应条件
1: bromobenzene With tert.-butyl lithium in tetrahydrofuran
T=-78°C; 0.5 h; Inert atmosphere;
2: With bromo(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)dimethylgermane in tetrahydrofuran
T=-78°C; 16 h; Inert atmosphere;
3: 1-benzyl-1,2,3,6-tetrahydropyridin-4-yl trifluoromethanesulfonate chemoselective reactionFurther stages;
参考文献
Spivey, Alan C.; Martin, Laetitia J.; Tseng, Chih-Chung; Ellames, George J.; Kohler, Andrew D.
Organic and Biomolecular Chemistry, 2008 , vol. 6, # 22 p. 4093 - 4095
参考文献
Grishina; Borisenko; Nosan'; Veselov; Ashkinadze; Karamov; Kornilaeva; Zefirov
Doklady Chemistry, 2003 , vol. 391, # 4-6 p. 195 - 199
参考文献
Schmidle; Mansfield
Journal of the American Chemical Society, 1956 , vol. 78, p. 425,426
反应条件
1: 70 percent / dimethylformamide / 70 °C
2: 77 percent / tetrahydrofuran / 0 °C
3: 91 percent / P2O5 / toluene / Heating
View Scheme
参考文献
Sakamuri, Sukumar; Enyedy, Istvan J; Kozikowski, Alan P; Zaman, Wahiduz A; Johnson, Kenneth M; Wang, Shaomeng
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 495 - 500
反应条件
1: 70 percent / dimethylformamide / 70 °C
2: 77 percent / tetrahydrofuran / 0 °C
3: 91 percent / P2O5 / toluene / Heating
View Scheme
参考文献
Sakamuri, Sukumar; Enyedy, Istvan J; Kozikowski, Alan P; Zaman, Wahiduz A; Johnson, Kenneth M; Wang, Shaomeng
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 495 - 500
反应条件
1.1: iodine; magnesium / tetrahydrofuran / Inert atmosphere; Reflux
1.2: 3 h / 20 °C / Inert atmosphere; Cooling with ice
2.1: methanesulfonic acid / toluene / 4 h / Reflux
View Scheme
参考文献
Conway, Richard J.; Valant, Celine; Christopoulos, Arthur; Robertson, Alan D.; Capuano, Ben; Crosby, Ian T.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 7 p. 2560 - 2564
反应条件
1: acetonitrile / 0.25 h / 85 °C / |Reflux
2: [{(η5-C5Me5)IrCl}2(μ-Cl)2]; potassium iodide; triethylammonium formate / dichloromethane / 24 h / 40 °C / |Sealed tube
View Scheme
参考文献
Wu, Jianjun; Tang, Weijun; Pettman, Alan; Xiao, Jianliang
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 1 p. 35 - 40
参考文献
Grishina; Borisenko; Nosan'; Veselov; Ashkinadze; Karamov; Kornilaeva; Zefirov
Doklady Chemistry, 2003 , vol. 391, # 4-6 p. 195 - 199
