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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
4-氧代-维A酸
合成路线
（共 12 条）
71748-57-7
4-氧代13-顺式-维甲酸甲基酯
→
反应条件
38030-57-8
4-氧代-维A酸
反应条件
potassium hydroxide in methanol; water 14 h; Heating;
参考文献
Mironova; Leont'eva; Shevyakov; Alexeeva; Shvets; Demina; Krasnokutskaya; Finkel'shtein; Khodonov
Russian Journal of Bioorganic Chemistry, 2002 , vol. 28, # 6 p. 487 - 493
38030-59-0
→
反应条件
38030-57-8
4-氧代-维A酸
反应条件
1: 84 percent / MnO2 / CH2Cl2 / 1 h / Ambient temperature 2: 72 percent / KOH / methanol; H2O / 0.33 h / Heating View Scheme
参考文献
Rosenberger
Journal of Organic Chemistry, 1982 , vol. 47, # 9 p. 1698 - 1701
81121-19-9
→
反应条件
38030-57-8
4-氧代-维A酸
反应条件
1: 73 percent / sodium methoxide / 0.5 h / Heating 2: 84 percent / MnO2 / CH2Cl2 / 1 h / Ambient temperature 3: 72 percent / KOH / methanol; H2O / 0.33 h / Heating View Scheme
参考文献
Rosenberger
Journal of Organic Chemistry, 1982 , vol. 47, # 9 p. 1698 - 1701
72526-76-2
→
反应条件
38030-57-8
4-氧代-维A酸
反应条件
potassium hydroxide; acetic acid 1) ethanol, water, reflux, 30 min; 2) pH 5.5, 45 min; Yield given. Multistep reaction;
参考文献
Aig, Edward; Focella, Antonino; Parrish, David R.; Rosenberger, Michael; Scott, John W.; Zenchoff, Gladys B.
Synthetic Communications, 1987 , vol. 17, # 4 p. 419 - 430
63184-93-0
→
反应条件
38030-57-8
4-氧代-维A酸
反应条件
1: 60 percent / sodium methoxide / CH2Cl2; methanol / 1) -20 - -24 deg C, 8 min; 2) room temperature, 2 h 2: 1.) potassium hydroxide, 2.) glacial acetic acid / 1) ethanol, water, reflux, 30 min; 2) pH 5.5, 45 min View Scheme
参考文献
Aig, Edward; Focella, Antonino; Parrish, David R.; Rosenberger, Michael; Scott, John W.; Zenchoff, Gladys B.
Synthetic Communications, 1987 , vol. 17, # 4 p. 419 - 430
302-79-4
维生素A酸
→
反应条件
38030-57-8
4-氧代-维A酸
+
66592-72-1
(2E,4E,6E,8E)-9-(3-羟基-2,6,6-三甲基-1-环己烯基)-3,7-二甲基-壬-2,4,6,8-四烯酸
反应条件
N-acetylglucosaminyltransferase I-negative HEK-293S cells transfected with cytochrome P450 enzymes CYP26A1 (HEK-CYP26A1 cells) 4 h; Enzymatic reaction; Product distribution / selectivity;
参考文献
UNIVERSITY OF WASHINGTON
Patent: US2008/249042 A1, 2008 ;
Location in patent: Page/Page column 2; 27; 29; 31; Sheet 14/24; 24/24 ;
33532-44-4
(2Z,4E,6Z,8E)-3,7-二甲基-9-(2,6,6-三甲基-3-氧代-1-环己烯基)壬-2,4,6,8-四烯醛
→
反应条件
38030-57-8
4-氧代-维A酸
反应条件
1: 70 percent / manganese dioxide; acetic acid; sodium cyanide / 4 - 20 °C 2: 87 percent / potassium hydroxide / methanol; H2O / 14 h / Heating View Scheme
参考文献
Mironova; Leont'eva; Shevyakov; Alexeeva; Shvets; Demina; Krasnokutskaya; Finkel'shtein; Khodonov
Russian Journal of Bioorganic Chemistry, 2002 , vol. 28, # 6 p. 487 - 493
62054-49-3
3-甲酰基-2-丁烯酸乙酯
+
63184-93-0
→
反应条件
38030-57-8
4-氧代-维A酸
反应条件
potassium hydroxide; sodium methylate 1.) dichloromethane, methanol, 0 deg C, 90 min, 2.) methanol, water, reflux, 45 min; Yield given. Multistep reaction;
参考文献
Rosenberger
Journal of Organic Chemistry, 1982 , vol. 47, # 9 p. 1698 - 1701
81121-21-3
→
反应条件
38030-57-8
4-氧代-维A酸
+
66592-72-1
(2E,4E,6E,8E)-9-(3-羟基-2,6,6-三甲基-1-环己烯基)-3,7-二甲基-壬-2,4,6,8-四烯酸
反应条件
potassium hydroxide; acetic acid 1) ethanol, waterreflux, 30 min; 2) CH2Cl2, pH 5.5, 30 min; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Aig, Edward; Focella, Antonino; Parrish, David R.; Rosenberger, Michael; Scott, John W.; Zenchoff, Gladys B.
Synthetic Communications, 1987 , vol. 17, # 4 p. 419 - 430
1425830-36-9
→
反应条件
反应条件
cytochrome P450 reductase; cytochrome P450 26A1 enzyme; water in aq. phosphate buffer T=37°C; pH=7.4; Enzymatic reaction; Kinetics; Concentration;
参考文献
Shimshoni, Jakob A.; Roberts, Arthur G.; Scian, Michele; Topletz, Ariel R.; Blankert, Sean A.; Halpert, James R.; Nelson, Wendel L.; Isoherranen, Nina
Journal of Biological Chemistry, 2012 , vol. 287, # 50 p. 42223 - 42232
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