4-(二甲基氨基)四氢-2H-吡喃合成路线 （共 4 条）
反应条件
5 palladium on charcoal; hydrogen in tetrahydrofuran T=0 - 10°C; P=1500.15 Torr; 4 h; Inert atmosphereLarge scale;
参考文献
Ikemoto, Tomomi; Ito, Tatsuya; Hashimoto, Hideo; Kawarasaki, Tadao; Nishiguchi, Atsuko; Mitsudera, Hiroyuki; Wakimasu, Mitsuhiro; Tomimatsu, Kiminori
Organic Process Research and Development, 2000 , vol. 4, # 6 p. 520 - 525
反应条件
hydrogenchloride; formic acid; sodium chloride in water; N,N-dimethyl-formamide
参考文献
Takeda Chemical Industries, Ltd.
Patent: US6166006 A1, 2000 ;
US 6166006 A
反应条件
formic acid T=140°C; reductive amination; 23 h;
参考文献
Shiraishi, Mitsuru; Aramaki, Yoshio; Seto, Masaki; Imoto, Hiroshi; Nishikawa, Youichi; Kanzaki, Naoyuki; Okamoto, Mika; Sawada, Hidekazu; Nishimura, Osamu; Baba, Masanori; Fujino, Masahiko
Journal of Medicinal Chemistry, 2000 , vol. 43, # 10 p. 2049 - 2063
参考文献
Cerkovnikov; Prelog
Chemische Berichte, 1941 , vol. 74, p. 1648,1652
