(5R)-3-(3-氟苯基)-5-[[(甲磺酰)氧]甲基]-2-恶唑烷酮合成路线 （共 7 条）
反应条件
1: (5R)-3-(3-fluorophenyl)-5-hydroxymethyloxazolidin-2-one With triethylamine in toluene T=85°C; 2: methanesulfonyl chloride in water; toluene T=15 - 75°C; 2.67 h;
参考文献
WO2005/116017 A1, ;
Page/Page column 23 ;
反应条件
1: sodium hydrogencarbonate / water; acetone / 0 °C 2: n-butyllithium / tetrahydrofuran / -78 - 20 °C 3: triethylamine / dichloromethane View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 18 p. 5266 - 5269
反应条件
1: 10 palladium on activated charcoal; hydrogen / tetrahydrofuran 2: sodium hydrogencarbonate / water; acetone / 0 °C 3: n-butyllithium / tetrahydrofuran / -78 - 20 °C 4: triethylamine / dichloromethane View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 18 p. 5266 - 5269
反应条件
triethylamine in dichloromethane
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 18 p. 5266 - 5269
反应条件
1: sodium azide / N,N-dimethyl-formamide / 70 °C 2: triphenylphosphine / tetrahydrofuran; water / 50 °C 3: triethylamine / dichloromethane / 0 - 20 °C View Scheme
参考文献
Khera, Manoj Kumar; Cliffe, Ian A.; Prakash, Om
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5266 - 5269
反应条件
sodium azide in N,N-dimethyl-formamide T=70°C;
参考文献
Khera, Manoj Kumar; Cliffe, Ian A.; Prakash, Om
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5266 - 5269
反应条件
1: sodium azide / N,N-dimethyl-formamide / 70 °C
2: triphenylphosphine / tetrahydrofuran; water / 50 °C
3: triethylamine / dichloromethane / 0 - 20 °C
4: iodine; silver trifluoroacetate / chloroform; acetonitrile
View Scheme
参考文献
Khera, Manoj Kumar; Cliffe, Ian A.; Prakash, Om
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5266 - 5269
