5-溴-2-(1H-四唑-5-基)吡啶合成路线 （共 10 条）
反应条件
sodium azide; ammonium chloride in DMF (N,N-dimethyl-formamide) T=20 - 110°C; 3 h;
参考文献
Im, Weon Bin; Choi, Sun Ho; Park, Ju-Young; Choi, Sung Hak; Finn, John; Yoon, Sung-Hwa
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 4 p. 1027 - 1039
反应条件
1: 65 percent / NaCN / dimethylformamide / 3 h / Heating 2: sodium azide / dimethylformamide / 4 h / 120 °C View Scheme
参考文献
Im, Weon Bin; Choi, Sun Ho; Park, Ju-Young; Choi, Sung Hak; Finn, John; Yoon, Sung-Hwa
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 4 p. 1027 - 1039
反应条件
sodium hydroxide in DMF (N,N-dimethyl-formamide) T=0 - 20°C; 2 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/56818 A1, 2004 ;
Location in patent: Page 52-53 ;
WO 2004/056818 A1
反应条件
sodium hydroxide in N,N-dimethyl-formamide T=0 - 20°C; Inert atmosphere;
参考文献
Im, Weon Bin; Choi, Sun Ho; Park, Ju-Young; Choi, Sung Hak; Finn, John; Yoon, Sung-Hwa
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 4 p. 1027 - 1039
反应条件
N-ethyl-N,N-diisopropylamine in methanol; acetonitrile T=0°C; 1.5 h;
参考文献
Clark, Richard F.; Djuric, Stevan; Ma, Zhenkun; Phan, Ly; Rupp, Michael
Patent: US2004/33970 A1, 2004 ;
Location in patent: Page/Page column 9 ;
反应条件
1: With acetic anhydride in pyridine
T=20 - 130°C; 1.5 h;
2: With hydrogenchloride in pyridine; water
pH=3 - 4;
参考文献
Gordeev, Mikhail Fedorovich; Yuan, Zhengyu; Liu, Jinqian; Wang, Qiang
Patent: US2010/69441 A1, 2010 ;
Location in patent: Page/Page column 39 ;
参考文献
Im, Weon Bin; Choi, Sun Ho; Park, Ju-Young; Choi, Sung Hak; Finn, John; Yoon, Sung-Hwa
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 4 p. 1027 - 1039
反应条件
sodium hydroxide in DMF (N,N-dimethyl-formamide)
T=0 - 20°C; 2 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/56818 A1, 2004 ;
Location in patent: Page 52-53 ;
WO 2004/056818 A1
反应条件
sodium hydroxide in N,N-dimethyl-formamide
T=0 - 20°C; Inert atmosphere;
参考文献
Im, Weon Bin; Choi, Sun Ho; Park, Ju-Young; Choi, Sung Hak; Finn, John; Yoon, Sung-Hwa
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 4 p. 1027 - 1039
反应条件
N-ethyl-N,N-diisopropylamine in methanol; acetonitrile
T=0°C; 1.5 h;
参考文献
Clark, Richard F.; Djuric, Stevan; Ma, Zhenkun; Phan, Ly; Rupp, Michael
Patent: US2004/33970 A1, 2004 ;
Location in patent: Page/Page column 9 ;
