5-溴-2-(1-甲基-1H-四唑-5-基)-吡啶合成路线 （共 7 条）
反应条件
sodium hydroxide in DMF (N,N-dimethyl-formamide)
T=0 - 20°C; 2 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/48350 A2, 2004 ;
Location in patent: Page 60-61 ;
WO 2004/048350 A2
反应条件
sodium hydroxide in N,N-dimethyl-formamide
T=0 - 20°C; Inert atmosphere;
参考文献
Im, Weon Bin; Choi, Sun Ho; Park, Ju-Young; Choi, Sung Hak; Finn, John; Yoon, Sung-Hwa
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 4 p. 1027 - 1039
反应条件
N-ethyl-N,N-diisopropylamine in methanol; acetonitrile
T=0°C; 1.5 h;
参考文献
Clark, Richard F.; Djuric, Stevan; Ma, Zhenkun; Phan, Ly; Rupp, Michael
Patent: US2004/33970 A1, 2004 ;
Location in patent: Page/Page column 9 ;
反应条件
1: 65 percent / NaCN / dimethylformamide / 3 h / Heating
2: sodium azide / dimethylformamide / 4 h / 120 °C
3: 1.0 g / KOH / dimethylformamide / 24 h / 20 °C
View Scheme
参考文献
Jo, Yeong Woo; Im, Weon Bin; Rhee, Jae Keol; Shim, Mi Ja; Kim, Won Bae; Choi, Eung Chil
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 22 p. 5909 - 5915
反应条件
1: sodium azide / dimethylformamide / 4 h / 120 °C
2: 1.0 g / KOH / dimethylformamide / 24 h / 20 °C
View Scheme
参考文献
Jo, Yeong Woo; Im, Weon Bin; Rhee, Jae Keol; Shim, Mi Ja; Kim, Won Bae; Choi, Eung Chil
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 22 p. 5909 - 5915
反应条件
1: sodium cyanide / N,N-dimethyl-formamide / 7 h / 150 °C / Inert atmosphere
2: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 3 h / 110 °C / Inert atmosphere
3: sodium hydroxide / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Im, Weon Bin; Choi, Sun Ho; Park, Ju-Young; Choi, Sung Hak; Finn, John; Yoon, Sung-Hwa
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 4 p. 1027 - 1039
反应条件
1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 3 h / 110 °C / Inert atmosphere
2: sodium hydroxide / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Im, Weon Bin; Choi, Sun Ho; Park, Ju-Young; Choi, Sung Hak; Finn, John; Yoon, Sung-Hwa
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 4 p. 1027 - 1039
