4-(N-Boc-氨基)苯硼酸合成路线 （共 9 条）
反应条件
hydrogenchloride; polystyrene boronic acid in acetonitrile T=20°C; 18 h;
参考文献
Pennington, Thomas E.; Kardiman, Cynantya; Hutton, Craig A.
Tetrahedron Letters, 2004 , vol. 45, # 35 p. 6657 - 6660
反应条件
4-(N,N-dimethlyamino)pyridine in acetonitrile T=20°C; 12 h;
参考文献
Banala, Ashwini K.; Zhang, Peng; Plenge, Per; Cyriac, George; Kopajtic, Theresa; Katz, Jonathan L.; Loland, Claus Juul; Newman, Amy Hauck
Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9709 - 9724
参考文献
Thrash, Thomas; Cabell, Larry A.; Lohse, Daniel; Budde, Raymond J.A.
Patent: US2006/4002 A1, 2006 ;
Location in patent: Page/Page column 40 ;
反应条件
palladium diacetate; potassium carbonate in tetrahydrofuran; water Suzuki-Miyaura coupling; 12 h; Inert atmosphereReflux;
参考文献
Journal of Organic Chemistry, , vol. 74, # 3 p. 1381 - 1384
反应条件
1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1 h / Reflux; Inert atmosphere 2: trifluoroacetic acid / dichloromethane / 3 h / 20 °C View Scheme
参考文献
PATHWAY THERAPEUTICS INC.; REWCASTLE, Gordon, William; GIDDENS, Anna, Claire; GAMAGE, Swarnalatha, Akuratiya
Patent: WO2012/44641 A1, 2012 ;
WO 2012/044641 A1
反应条件
potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in 1,4-dioxane; water 1 h; RefluxInert atmosphere;
参考文献
WO2012/44641 A1, ;
Page/Page column 46; 82-84 ;
WO 2012/044641 A1
反应条件
potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in 1,4-dioxane 1 h; Inert atmosphereReflux;
参考文献
US2010/249099 A1, ;
Page/Page column 82 ;
US 20100249099 A1
反应条件
1: aq. Na2CO3 / [Pd(PPh3)4] / 1,2-dimethoxy-ethane / 18 h / Heating 2: 76 percent / TFA / CH2Cl2 / 2 h / 20 °C View Scheme
参考文献
Ishi-I, Tsutomu; Kuwahara, Rempei; Takata, Akihiko; Jeong, Yeonhwan; Sakurai, Kazuo; Mataka, Shuntaro
Chemistry - A European Journal, 2006 , vol. 12, # 3 p. 763 - 776
反应条件
1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1 h / Reflux; Inert atmosphere 2: trifluoroacetic acid / dichloromethane / 3 h / 20 °C 3: pyridine / 2.5 h / 0 °C View Scheme
参考文献
PATHWAY THERAPEUTICS INC.; REWCASTLE, Gordon, William; GIDDENS, Anna, Claire; GAMAGE, Swarnalatha, Akuratiya
Patent: WO2012/44641 A1, 2012 ;
WO 2012/044641 A1
