(2-{[2-(羟基甲基)苯基]硫代}苯基)甲醇合成路线 （共 9 条）
反应条件
1: With borane-THF in tetrahydrofuran
T=20°C; 16 h;
2: With methanol; water in tetrahydrofuran
Product distribution / selectivity;
参考文献
XENON PHARMACEUTICALS INC.
Patent: US2008/234384 A1, 2008 ;
Location in patent: Page/Page column 56 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran; diethyl ether
T=20°C; 16 h;
2: With water; sodium sulfate in tetrahydrofuran; diethyl ether
Product distribution / selectivity;
参考文献
XENON PHARMACEUTICALS INC.
Patent: US2008/234384 A1, 2008 ;
Location in patent: Page/Page column 47 ;
反应条件
1: 4,4'-diphenylsulfide With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in hexane
T=0°C; 24 h;
2: formaldehyd in hexane
48 h; Reflux;
参考文献
Martinez-Otero, Diego; Alvarado-Rodriguez, Jose G.; Cruz-Borbolla, Julian; Andrade-Lopez, Noemi; Pandiyan, Thangarasu; Moreno-Esparza, Rafael; Flores-Alamo, Marcos; Cantillo-Castillo, Jesus
Polyhedron, 2012 , vol. 33, # 1 p. 367 - 377
反应条件
1: 1 h / Heating
2: 65 percent / LiAlH4 / diethyl ether / 12 h / Heating
View Scheme
参考文献
Raguse, Burkhard; Ridley, Damon D.
Australian Journal of Chemistry, 1988 , vol. 41, # 12 p. 1943 - 1952
反应条件
1: 1.) NaOH, 2.) Cu powder / 1.) EtOH, H2O, 2.) 275 deg C
2: SOCl2 / 5 h / Heating
3: 1 h / Heating
4: 65 percent / LiAlH4 / diethyl ether / 12 h / Heating
View Scheme
参考文献
Raguse, Burkhard; Ridley, Damon D.
Australian Journal of Chemistry, 1988 , vol. 41, # 12 p. 1943 - 1952
反应条件
1: 1.) NaOH, 2.) Cu powder / 1.) EtOH, H2O, 2.) 275 deg C
2: SOCl2 / 5 h / Heating
3: 1 h / Heating
4: 65 percent / LiAlH4 / diethyl ether / 12 h / Heating
View Scheme
参考文献
Raguse, Burkhard; Ridley, Damon D.
Australian Journal of Chemistry, 1988 , vol. 41, # 12 p. 1943 - 1952
反应条件
ethylmagnesium bromide
1) THF, reflux, 8h; Yield given. Multistep reaction;
参考文献
Furukawa, Naomichi; Ogawa, Satoshi; Matsumura, Kazunori; Shibutani, Tadao; Fujihara, Hisashi
Chemistry Letters, 1990 , # 6 p. 979 - 982
参考文献
Reissert; Craemer
Chemische Berichte, 1928 , vol. 61, p. 2559
反应条件
pyridinium chlorochromate in dichloromethane
T=20°C; 4 h;
参考文献
Rachwalski, Michal; Leenders, Tim; Kaczmarczyk, Sylwia; Kielbasinski, Piotr; Lesniak, Stanislaw; Rutjes, Floris P. J. T.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 25 p. 4207 - 4213
