2-甲氧基-6(5H)-菲啶酮合成路线 （共 12 条）
反应条件
1: With potassium hydroxide in tert-butyl alcohol
T=150°C; 1.25 h; Microwave irradiation;
2: With hydrogenchloride in water; tert-butyl alcohol
参考文献
Dubost, Emmanuelle; Magnelli, Rosa; Cailly, Thomas; Legay, Remi; Fabis, Frederic; Rault, Sylvain
Tetrahedron, 2010 , vol. 66, # 27-28 p. 5008 - 5016
反应条件
1: 2-Iodo-benzoic acid ethyl ester With isopropylmagnesium chloride in tetrahydrofuran; ethylene glycol dimethyl ether
0.5 h;
2: in tetrahydrofuran; ethylene glycol dimethyl ether
0.333333 h;
3: N-(2-iodo-4-methoxyphenyl)-4-methoxybenzamide With iron (III) acetylacetonate in tetrahydrofuran; ethylene glycol dimethyl ether
T=80°C; 2 h; Further stages.;
参考文献
Kofink, Christiane C.; Blank, Benoit; Pagano, Sandro; Goetz, Nadine; Knochel, Paul
Chemical Communications, 2007 , # 19 p. 1954 - 1956
反应条件
copper(l) iodide in N,N-dimethyl-formamide
5 h; Heating;
参考文献
Patil, Shivaputra; Kamath, Shantaram; Sanchez, Tino; Neamati, Nouri; Schinazi, Raymond F.; Buolamwini, John K.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 3 p. 1212 - 1228
反应条件
1,10-phenanthroline; potassium tert-butylate in benzene
T=110°C; 24 h;
参考文献
Bhakuni, Bhagat Singh; Kumar, Amit; Balkrishna, Shah Jaimin; Sheikh, Javeed Ahmed; Konar, Sanjit; Kumar, Sangit
Organic Letters, 2012 , vol. 14, # 11 p. 2838 - 2841
反应条件
1.1: 89 percent / pyridine / dioxane / 2 h / 20 °C
2.1: iPrMgCl / tetrahydrofuran; 1,2-dimethoxy-ethane / 0.5 h
2.2: CuCN*2LiCl / tetrahydrofuran; 1,2-dimethoxy-ethane / 0.33 h
2.3: Fe(acac)3 / tetrahydrofuran; 1,2-dimethoxy-ethane / 2 h / 80 °C
View Scheme
参考文献
Kofink, Christiane C.; Blank, Benoit; Pagano, Sandro; Goetz, Nadine; Knochel, Paul
Chemical Communications, 2007 , # 19 p. 1954 - 1956
反应条件
1.1: 89 percent / pyridine / dioxane / 2 h / 20 °C
2.1: iPrMgCl / tetrahydrofuran; 1,2-dimethoxy-ethane / 0.5 h
2.2: CuCN*2LiCl / tetrahydrofuran; 1,2-dimethoxy-ethane / 0.33 h
2.3: Fe(acac)3 / tetrahydrofuran; 1,2-dimethoxy-ethane / 2 h / 80 °C
View Scheme
参考文献
Kofink, Christiane C.; Blank, Benoit; Pagano, Sandro; Goetz, Nadine; Knochel, Paul
Chemical Communications, 2007 , # 19 p. 1954 - 1956
反应条件
2,2'-azo-bisisobutyronitrile; potassium tert-butylate in benzene
T=81°C; 24 h;
参考文献
Bhakuni, Bhagat Singh; Shrimali, Kaustubh; Kumar, Amit; Kumar, Sangit
Organic Syntheses, 2013 , vol. 90, p. 164 - 173
反应条件
1: 70 percent / NBS / dimethylformamide
2: 83 percent / cuprous iodide / dimethylformamide / 5 h / Heating
View Scheme
参考文献
Patil, Shivaputra; Kamath, Shantaram; Sanchez, Tino; Neamati, Nouri; Schinazi, Raymond F.; Buolamwini, John K.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 3 p. 1212 - 1228
反应条件
2: cyclohexane / Irradiation; aerated and deaerated solutions
View Scheme
参考文献
Grimshaw, James; Silva, A. Prasanna de
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1982 , p. 857 - 866
反应条件
2: cyclohexane / Irradiation; aerated and deaerated solutions
View Scheme
参考文献
Grimshaw, James; Silva, A. Prasanna de
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1982 , p. 857 - 866
