8-氯-6,11-二氢-11-(1-甲基-4-哌啶基)-5H-苯并[5,6]环庚烷[1,2-b]吡啶-11-醇合成路线 （共 5 条）
反应条件
in tetrahydrofuran Reflux;
参考文献
Liu, Wukun; Zhou, Jinpei; Zhang, Tong; Zhu, Haiyang; Qian, Hai; Zhang, Huibin; Huang, Wenlong; Gust, Ronald
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 8 p. 2701 - 2704
反应条件
1: 4-chloro-1-methyl-piperidine With magnesium; ethylene dibromide in tetrahydrofuran T=20 - 48°C; 2: 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one in tetrahydrofuran T=-80 - -70°C; 2 - 3 h; Product distribution / selectivity;
参考文献
MOREPEN LABORATORIES LIMITED
Patent: WO2006/6184 A2, 2006 ;
Location in patent: Page/Page column 15 ;
反应条件
sulfuric acid T=20°C; 4.5 h;
参考文献
Liu, Wukun; Zhou, Jinpei; Zhang, Tong; Zhu, Haiyang; Qian, Hai; Zhang, Huibin; Huang, Wenlong; Gust, Ronald
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 8 p. 2701 - 2704
反应条件
1: sulfuric acid / 4.5 h / 20 °C 2: triethylamine / toluene / 3 h / Reflux View Scheme
参考文献
Liu, Wukun; Zhou, Jinpei; Zhang, Tong; Zhu, Haiyang; Qian, Hai; Zhang, Huibin; Huang, Wenlong; Gust, Ronald
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 8 p. 2701 - 2704
反应条件
1: sulfuric acid / 4.5 h / 20 °C 2: triethylamine / toluene / 3 h / Reflux 3: potassium hydroxide / ethanol / 6 h / Reflux View Scheme
参考文献
Liu, Wukun; Zhou, Jinpei; Zhang, Tong; Zhu, Haiyang; Qian, Hai; Zhang, Huibin; Huang, Wenlong; Gust, Ronald
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 8 p. 2701 - 2704
